Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: 240003 Date: 10/12/2018
Subject Name: Pharmaceutical Chemistry IV
Time:02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Define following
1. Optical activity 2. Chirality 3. Configuration
4. Racemic mixture 5. Geometrical isomerism 6. Tautomerism
06

Write an informative note on Stereochemistry of Biphenyl.
05

Discuss the Haworth synthesis for naphthalene.
05
Q.2

Discuss any three-general method of preparation and three reactions of amines.
06

Discuss Grignard reagents utility in organic chemistry with specific example.
05

Give any three methods of preparations of Phenols.
05
Q.3

Explain the following statements.
1. Ammonia is more basic than aniline.
2. Acetone is less reactive than Acetaldehyde
3. Chloroacetic acid is stronger than acetic acid
06

Give mechanism for Kolbe reaction.
05

Explain enantiomer and diastereomer with one common example.
05
Q.4

Describe preparation and synthetic utility of diazonium slats.
06

Give the chemistry of anthracene
05

Give mechanism for Diels alder reaction
05
Q.5

Give the method for preparation of carboxylic acid.
06

Write a note on Witting reaction.
05
Give mechanism for Reimer-Tiemann reaction.
05
Q. 6

How will you convert
1. Phenol to Aspirin 2. Aniline to Phenol 3. Aniline to p-Nitro Aniline
06

Write a note on Microwave synthesis.
05

Give any three chemical reactions of
1. Amides 2. Ketone
05
Q.7

What is Green chemistry? Discuss any four principles of it.
06

Give the mechanism of Sulphonation and Chlorination of benzene.
05
Give a brief discussion on acidity of carboxylic acids.
05