Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: 230003 Date: 14/12/2018
Subject Name: Pharmaceutical Chemistry III
Time: 10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Comment on methods of preparation of alkanes.
06

Explain Bond energy Lewis acid Vander walls forces Ionic bond Polarity.
05

Write a note on molecular orbital theory.
05
Q.2

Enlist the methods used to determine molecular weight of organic compound. Discuss any two in details.
06

Write a detailed note on carbocation.
05

Enlist the reactions of alcohols. Comment on its reaction with metals.
05
Q.3

Write a note on Kjehldahl's method of nitrogen estimation.
06

Write a note on Oxo process.
05

Write a note on hydroboration oxidation reaction of alkenes.
05
Q.4

Give reason Acetylene is a linear molecule.
Alkyl halides give nucleophilic substitution while aryl halides dont.
Addition reactions of alkenes follows Markownikoff,s rule.
06

Write a note on cycloaddition reactions.
05

Write a note on crown ethers.
05
Q.5

Give the structure of t-butyl ethyl ether iso-pentyl alcohol 3,6-dimethyl-1-octene 4-methyl hept-2-en-5-yn-1-ol 1,3 cyclohexadiene dimethyl acetylene.
06

What are dienes? Comment on stability of conjugated dienes.
05

Write a note on Williamson's synthesis.
05
Q. 6

What are alcohols? Comment on their nomenclature and physical properties.
06

Write a note on reactions of epoxides.
05

Comment on resonance and hyper-conjugation.
05
Q.7

What are alkynes? Comment on method of preparations of alkynes.
06

Write a note on sigmatropic reactions
05

Define Carbene nitrene hybridization electronegativity covalent bond
05