1 HIV/ AIDS is diagnosed by some specific tests. Identify which among the following test/s is/are used

ELISA

DNA -PCR by amplification

Western blot

All the above

2 What is the antidote for Lead poisoning?

Dimercaptosuccinic acid

Physostigmine

FomepizoIe

Atropine

3 Which of the following drugs is not a TocoIytic

Ritoderine

Magnesium sulfate

Nifedipine

Ergotamine

4 VVhich of the following NSAIDs is not a propionic acid derivative?

Ibuprofen

Naproxen

Oxaprozin

Piroxicam

5 Which anticoagulant is produced by mast cells and basophils

Heparin

Prostaglandin

Histidine

Vitamin K

6 Under which rule of Drugs and Cosmetics Act, 1940 and rules 1945, licences for blood banks are issued

122G

122A

160B

150B

7 Match the following: Thromboplastin Factor VII Proconvertin Factor III Fibrinogen Factor II Prothrombin Factor I Codes:







Cfi'<Ji:lli CfiiQmi<:il /SPACE FOR ROUGH WORK P.T.D. J07 4 A

8 Basophils originate in Megakaryoblast Megakaryocyte Monoblast Myeloblast

9 Match the following anticancer drugs with their cell cycle effects: Cytarabine G1 phase Etoposide M phase Vincristine G2 phase Bleomycin S phase Codes:









10 Which of the following is an ester and short-acting Local anaesthetic?

Tetracaine

Dibucaine

Lidocaine

Procaine

11 Antifungal Antibiotic Amphotericin B is obtained from:

Streptomyces pimprina

Penicillum griseofulvin

Streptomyces nodosus

Both and

12 Which of the following drugs is not an enzyme -inducer?

Phenobarbitone

Phenytoin

Rifampin

Cirnetidine

13 One of the following drugs is most widely used as local anaesthetic for infiltration, regional nerve block, epidural and subarachnoid anaesthesia. It is also commonly used for topical anaesthesia:

Cocaine hydrochloride

Procaine hydrochloride

Lid.ocaine hydrochloride

Mepivacaine hydrochloride ctli4ifli61 jSPACE FOR ROUGH WORK A 5 J07

14 Which of the following antiretroviral drugs belongs to Non-nucleoside reverse transcriptase inhibitors (NNRTI) category?

Nevirapine

Indinavir

Ritcinavir

Stavudine

15 Which of the following drugs induces delta-amino-Ievulinic-acid (ALA)-synthetase?

Phenobarbitone

Ethanol

Paraldehyde

Diazepam

16 Which of the following drugs is not a component of fixed-dose combination used in RNTCP for Tuberculosis?

Rifampicin

Moxifloxacin

Isoniazid

Ethambutol

17 Micro-organism responsible for sexually transmitted diseases which causes an eye infection that is the primary cause of blindness world wide:

Neisseria gonorrhoeae

Treponema paIIidum

Chlamydia trachomatis

Candida albicans

18 On which chromosome, the genes for three chains of fibrinogen are found?

chromosome 1

chromosome 3

chromosome 4

chromosome 6

19 Whole human blood is a mixture of blood and anticoagulant solution and contains not less than:

8.7% w/v of haemoglobin

2.3% w/v of haemoglobin

9.07% w/v of haemoglobin

9.7% w/v of haemoglobin

20 Match the following: Nor -adrenaline reuptake inhibitor Fluoxetine Serotonin reuptake inhibitor Phenelzine Mono amine oxidase inhibitor Dextroamphetamine Psychomotor stimulant Amitriptyline Codes:







CFilllHlIOl 'ffillT /SPACE FOR ROUGH WORR P.T.O. J076 A

21 The relative nephrotoxicity among the Non-steroidal anti-inflammatory drugs is one of the following

Indomethacin Fenoprofen Ibuprofen

Ibuprofen> Fenoprofen Indomethacin

Indomethacin> Fenoprofen Ibuprofen

Fenoprofen> Ibuprofen> Indomethacin

22 Which of the following antifungal drugs is used only topically?

Griseofulvin

Clotrimazole

Amphotericin

Nystatin

23 What is accepted daily intake in mg/kg/day of Aldrin?

0.005

0.008

0.0001

0.0005

24 Which of the following is Non-opioids Antitussive?

Codeine

Ethylmorphine

Dextromethorphan

Pholcodine

25 Match the columns Phenothiazines Suppresses inositol signalling A typical Antipsychotic M -Receptor Blockade Biltyrophenone Blockade of 5 -HTzA receptors Lithium Blockade of Dz receptors Codes:







itllqjl:lIJl 'lTl1T /SPACE FOR ROUGH WORK A 7 J07

26 Which one of the following drugs is uterine relaxant?

Oxytocin

Ergonovine

Ritodrine

Quinine

27 The selective angiotensin II receptor blocker used as antihypertensive drug is one of the following:

Captopril

Verapamil HCl

Amiloride

Losartan

28 What is the consequence of interaction between 6-Mercaptopurine and Allopurinol?

Dose of 6-Mercaptopurine is reduced

No effect

Dose of 6-Mercaptopurine is increased

Dose of Allopurinol is increased

29 For donors experiencing plasmapheresis, Aspirin should not have been taken day(s) prior to donation.

One

Three

Five

Seven

30 Which of the following oral contraceptive preparations contains an estrogen and a progestin in fixed doses for all the days of the treatment cycle?

MinipiIl

Emergency pill

Combined pill

Phased pill

31 During and after an attack of infeStious mononucleosis an agglutinin for sheep red blood cells appears in the serum and is of diagnostic significance. This agglutinin is demonstrated inthe

Rose -Waaler test

Differential sheep cell agglutination test

Paul -Bunnell test

MG agglutination test

32 Media that enhance the growth of a particular type of bacterium and do not enhance and even may inhibit other types of organisms are called:

Differential media

Selective media

Maintenance media

Assay media cwHflidl jSPACE FOR ROUGH WORK P.T.O. T07 8 A

33 In the laboratory diagnosis of rabies impression smears of the brain are stained by Seller's technique to demonstrate the inclusion bodies called

Negri bodies

Cowdry type A bodies

Cowdry type B bodies

Bollinger bodies

34 Lowbury and Lilly's medium, and Willis and Hobbs' medium are used for cultivation of

Bordetella

Clostridia

Bacilli

Corynebacteria

35 Alcohol in water (60 is a good disinfectant for medical instruments and laboratory surfaces. It destroys the microorganisms present there by

solubilizing lipids and protein denaturation

disrupting cell membrane

combining with-SH groups

acting as strong alkylating agent

36 pH indicator/dye present in Christensen's urea medium is

neutral red

andrade's indicator

methyl red

phenol red

37 Which of the following statements are true? The LAL test reagent is obtained from a horse shoe crab. The LAL test is more sensitive than the pyrogen test. The LAL test only detects endotoxins of gram negative bacteria. The LAL test can be used for radiopharmaceuticals. Codes:

and

and

and

and Cfil4iflldl 'ifIllT /SPACE FOR ROUGH WORK A 9 J07

38 The antimicrobial drug showing structural similarity to paraaminobenzoic acid and which is bacteriostatic is Penicillin Rifamycin Isoniazid SuIfonamides Which of the statement!s given above is(are correct

only

and only

and

only

39 Match the following Bioassay test organisms Vitamins Lactobacillus casei Cyanocobalamin LactobaciIIus leichmanii Inositol Lactobacillus arabinosus Biotin Saccharomyces uvarum Calcium pantothenate Codes:









40 The pyrogen test is designated to limit the risk of a febrile reaction following parenteral administration of drugs. It is intended to be used for liquid products that can be tolerated by the test in a dose of 10 mL per kg, injected intravenously.

rabbit white mice guinea pig hamster 410 Collodion filters are used for the isolation of Bacteria Algae Moulds Viruses 420 Diagnosis of Helicobacter pylori can be done by Urea breath test

Copper breath test

Sodium breath test

Potassium breath test ifliilOCll ifllqlflldl (SPACE FOR ROUGH WORK PoT.Oo J07 10 A

43 Which of the following is used to serodiagnose syphilis?

Veneral Disease Research Laboratory test

Widal test

Sereny test

Etest

44 Typical BOD values for domestic waste water, including sewage are units.

200 BOD

100 BOD

500 BOD

300 BOD

45 The major causes of common cold are:

Influenza viruses

Adenoviruses

Rhinoviruses

None of the above

46 Which of the following statement/s about antibiotics is/are incorrect Oral activity can be conferred on cephalosporins by esterification of the 3 -carboxylic acid group. Acylureidopenicillins are stable under acidic conditions. Aminoglycosides have a highly substituted 3 -diamino cyclohexane central ring. The enolized tricarbonyl methane system at C1 to C3 in the tetracycline structure need not be intact for good activity. Answer options

only

and only

and only

all of the above

47 Schedule M refers to

GMP and requirements of factory premises equipment for manufacture of drugs.

Standard of surgical dressings.

Life period of drugs.

Standard of cosmetics. 'lii'lifliJl 'ifTlTT /SPACE FOR ROUGH WORK A 11 J07

48 Who is the Chairman of the Drug Technical Advisory Board (DTAB)

Drugs Controller of India

The President

The President -Medical Council of India

Director -General of Health Services

49 Benzalkonium chloride which is used as Antimicrobial preservative can be used in what concentration

0.002 -0.02%

0.1

15%

30

50 Practical application of recombinant DNA technology is in the production of Interferon Insulin Growth Hormone Phospholipid Which of the above options are correct

and only

and only

and only

and only

51 Which of the following statement/s about Tautomerism islare correct Shifting of carbon atom from one hydrogen to an other to produce enantiomen is called tautomerism. Sugar with anomeric carbon undergoes tautomerism in acidic solution. Sugar with anomeric carbon undergoes tautomerism in alkaline solution. Shifting of atom from one carbon to another to produce enediols is called tautomerism. Answer options

only

only and

only and

only and

52 The most naturally occurring monosaccharides in mammalian tissue are of which configuration

D

L



",lqlfllGl ISPACE FOR ROUGH WORK P.T.O. J07 12 A

53 Physical properties of well formulated suspension and emulsion are: Product must remain sufficiently homogeneous. The sediment or creaming produced on storage is easily suspended by moderate agitation. Any suspended particle should be small and uniform in size. The product needs to be thickened to reduce settling rate of particles. Which of the statements given above are correct

and only

and only

and only

and

54 The concentration of phenyl ethyl alcohol as a preservative in ophthalmic suspensions is

0.01

0.5%

0.001

0.1%

55 Which of the following is water soluble coating material used in dosage form (solid)

Gelatin

Poraffin

Shellac

Nylon

56 Ketone bodies is the term collectively called for: acetoacetate 3 -hydroxy butyrate acetone ketone Answer options

and only

and only

and only

and

57 What are the factors affecting dosage form design common ion effect pka crystallization autoclaving Answer options

and

and

and

all of the above CfliQifli6l jSPACE FOR ROUGH WORK A 13 J07

58 "y -Aminobutyrate (GABA) is formed by decarboxylation of

L-arginine

L -glutamate

L -tyrosine

L -spermidine

59 Hemolytic anaemia can be caused by deficiency of following enzymejs of pentose phosphate pathway: glucose -phosphokinase 6 -phospho gluconate reductase glucose -phosphate dehydrogenase transketolase Answer options

and only

only

only

and only

60 A drug shall be deemed to be spurious: If it is manufactured under the name which belongs to another drug. If it has been substituted wholly or partially by another drug or another substance. If it purports to be a product of manufacturer of whom it is not truly a product. If it contains any harmful or toxic substances which may render it injurious to health. Which of the statements given above are correct

and only

and only

and only

and only

61 Match the enteric coating polymers with their synonyms: Cellulose acetate phthalate Sureteric Shellac Certiseal Polymethacrylate Aquacoat CPD Polyvinyl acetate phthalate Kollicoat MAE Codes:







ililqifliOl jSPACE FOR ROUGH WORK P.T.O. J07 14 A

62 Government Analyst is appointed by State and Central Governments under section 33 F of the Act for medicine: Ayurvedic Siddha Unani Allopathic Which of the options given above are correct

and only

and only

and only

,and

63 Which of the following statements(s is(are correct wifh respect to membrane controlled sustained release formulations Release of the drug is by disintegration, A plasticizer is required to lower the glass transition temperature of fhe film, Fillers that compact by brittle fracture are suitable if used alone, Water soluble components are not necessary to increase fhe rate of release. Answer options

only

only

only

all of fhe above

64 Wifh respect to suspensions the Stocks law of particles is related to which factor( s Diameter of particle Density of particle and medium Viscosity of medium Sedimentation rate Answer options

only

only and

only and

and

65 How many stereo isomers are possible for the compound: CH3 -CHz -CH3









66 Which of fhe following is not an anionic surfactant?

Carboxylic acid

Alkyl and alkyl-aryl sulfonate

Ammonium carboxylate

Substituted alkyl amide (SPACE FOR ROUGH WORK A 15 J07

67 The control test for gauging of surgical catgut is carried out at

RH 45 and temperature 30"C

RH 45% and temperature 25"C

Ambient temperature and humidity

RH 60 and temperature 16 -21"C

68 According to the schedule U the particulars shown of manufacturing records for substances other than parentral are Serial No. Name of product Lot/Batch size Reference of Master Formula record Which of fhe particulars given above are correct

and only

and only

and only

and

69 Drug shaH be deemed as misbranded: If it is not labeHed in a prescribed manner. Ifit is coloured, coated, powdered or polished so that damage is concealed or made to appear of greater therapeutic value than it reaHy is. If its label or container bears any statement, design or device which makes false claim for the drug. If it is prepared, stored or packed under insanitary condition. Which of fhe statements given above are correct

and only

and only

and only

and

70 In continuous fermentation, steady state is achieved using principles of

thermostat

levelstat

pH stat

chemostat

71 The important disaccharides are: . Sucrose Maltose Lactose CeHulose Which of fhe above options are correct

and only

and only

and only

and only Cfiillif1iOl "ITlTT /SPACE FOR ROUGH WORK P.T.O. J0716 A

72 According to D and C Act 1940 and R.T. 1945 schedule M-II is meant for the manufacture of:

Cosmetics

Medical devices

Pharmaceutical products

Allied products

73 Which of the following statements relating to DNA vaccines is correct?

Pathogen gene itself is used as vaccine either naked or inserted

Gene coding on immunological protein

Polysaccharide vaccine

Attenuated non-pathogenic

74 Identify the incorrect statement/s for an adulterated drug: It purports to be the product of a manufacturer of whom it is truly not a product. It is not labelled in the prescribed manner. It is a substitute for another drug. It bears a colour other than prescribed. Answer options

all of the above

and only

and only

only

75 In sustained release dosage forms, the drug release is retarded due to the presence of

special coat

embedded matrix

core tablet

granule mix

76 The Time period to supply information under the Right To Information Act concerning 'Life or Liberty of Person' is

24 hours

32 hours

72 hours

48 hours 'ffi'llT /SPACE FOR ROUGH WORK A 17 J07

77 List of Essential Drugs includes: Nucleoside Reverse Transcriptase Inhibitors. T -Zidovudine and its combinations. Insect Repellant -Diethyl toluamide, DDT etc. Antiparkinson's medicine -Levodopa, Carbidopa. Plasma substitutes -Tranexamic acid Answer options

All of the above

and only

and only

None of these

78 The foHowing pairs give GMP requirements as per the various schedules. Which of the following pairs is incorrect? .

Schedule T GMP requirements of Ayurvedic, Unani and Siddha Medicine

Schedule M -Requirements of Factory Premises for Manufacturing of Homeopathic Preparations

Schedule M -II -Requirements for manufacturing premises of cosmetics

Schedule N Requirements for manufacturing of medical devices

79 The present Drugs Controller General of India is

Dr. G.N. Singh

Dr. V.G. Somani

Dr. Harshadeep Kamble

Dr. S. Reddy

80 The key principles for the regulation of prices in the National Pharmaceutical Pricing Policy, 2012, are as follows Essentiality of Drugs Control of Formulation Prices only Market based Pricing Cost based Pricing Answer options

and only

and only

all of the above

none of the above

81 Consumer Protection Act, 1986 is applicable to the following area:

Maharashtra only

Madhya Pradesh only

Gujarat only

All over India except Jammu and Kashmir CfliQlfllJl jSPACE FOR ROUGH WORK P.T.O. J07 18 A

82 When was the minocycline, drug belonging to the category of antibiotics, cleared and approved by Drugs Controller General of India, New Delhi?

June, 1975

January, 2015

January, 1988

May, 1988

83 The functions of the Central Drug Laboratory in respect of the classes of the drugs are enlisted below Laboratory in respect of blood grouping and diagnostic kits for Hepatitis C virus -National Institute of Biologicals, Noida Laboratory with respect to VORL Antigen -Pasteur Institute, Conoor Indian Veterinary Research Institute -Haffkine, Parel Laboratory for Homeopathic medicines -Ghaziabad Which of the above pairs are true

and only

and only

and only

and only

84 Advertisements of drugs used in following diseases and disorders are prohibited: drugs for procurement of miscarriage drugs to correct menstrual disorders in women drugs to improve fairness drugs to improve the power of human beings for sexual pleasure Which of the above statements are correct

and only

and only

and only

and only

85 National Cancer Registry Programme which is a part of the National Cancer Control Programme was initiated in the year 1982 by which of the following organizations?

AICTE

UGC

ICMR

Tata Cancer Research Center qi'+llflidl jSPACE FOR ROUGH WORK A 19 J07

86 The main regulatory authorities which issue guidelines that are globally accepted and followed by Pharma Industries are: USFDA (United States Food and Drug Administration) UKMCA (The Medicine Control Agency) lCH (International Conference on Harmonization) WHO (World Health Organization) Answer options

and only

and only

All of the above

None of the above

87 The functions of Central Drug Laboratory in respect of any drug or class of drugs are carried out at Central Research Institute, Kasauli Prescribed laboratory by central government ISO certified laboratory NAAC accredited laboratory Answer options

only

and only

and only

and ohIy

88 Functional Foods are termed as neutraceuticals. Which of the following is/ are the example/s of neutraceuticals Isolated compounds Dietary supplements Designed foods Processed foods Answer options

only

only

only

and all

89 Narcotic Drugs include: Coca Leaf Acetorphine Cannabis Ketobernidone Which of the above options are correct

and only

and only

All of the above

None of the above CflIQlflidl iifI11T /SPACE FOR ROUGH WORK P.T.O. J07 20 A

90 For Import Licence which of the following statements is incorrect

Import Licence in Form 10 to import drugs is specified in schedule -X.

Import Ljcence in Form 10 is to import drugs excluding those specified in schedule -X.

An application for import Licence shall be made in Form 8 for Drugs excluding those specified in schedule -X.

An application for import licence shall be made in Form 9A for drugs specified in schedule X.

91 The permitted synthetic organic colours and natural colours used in the cosmetics shall not contain more than 2 parts per million of Arsenic calculated as Arsenic Trioxide 20 parts per million of lead calculated as lead 2 parts per million of mercury compounds 100 parts per million of Heavy Metals other than lead calculated as the total of the respective metals Answer options

and only

and only

and

and only

92 Poison Act, 1919 mentions The power of state government to regulate possession for sale and sale of any poison. Such rules give details pertaining to The grant of licences to possess any specified poison for sale, wholesale, retail and fixing of the fees to be charged for such licences. The classes of person to whom alone such licences may be granted or sold. The maximum quantity of any such poison which may be sold to anyone person. The maintenance of record by such vendors and the labelling, packaging and safe custody by person who sold or possessed it for sale. Which of the above statements are correct

and only

and only

and

None of these &ijQi@S jSPACE FOR ROUGH WORK A 21 J07

93 Drug will be deemed to be spurious if If it is imported under a name which belongs to another drug. If it is coloured, coated, powdered or polished so that damage is concealed. If it is not labelled in the prescribed manner. If it is made to appear of better or greater therapeutic value. Which of the above statement!s isjare correct

and only

and only

and only

only

94 Select the logically equivalent option with respect to the statement given below. "1£ Vma and Sohil go for a beach walk, then it is raining."

If it is not raining then Vma and Sohil do not go for a beach walk.

If Vma and Sohil do not go for a beach walk, then it is raining.

If Vma and Sohil do not go for a beach walk, then it is not raining.

If it is not raining then Vma and Sohil go for a beach walk.

95 Donu, Nanu and Yonu who belong to three different communities, participated in a chapati making competition and one of them won the trophy. They belong to communities namely Romi, Mori and Bori. All members of Romi community always make true statements, all members of Mori community always make untrue statements, all members of Bori community make true and untrue statements alternately. They made the following statements when reporter asked them to comment. Donu: IfYonu had not disturbed me by singing loudly while making chapatis I would have won the trophy. Yonu always speaks the truth. Yonu is the winner. Nanu: Donu won the trophy. Yonu is not the member of Mori community. Yonu: I was not singing to disturb Donu. Nanu won the trophy. Who won the trophy Answer options

Yonu

Donu

Nanu

Yonu and Donu jointly won the trophy q:)jqifli61 jSPACE FOR ROVGH WORK P.T.O. J07 22 A

96 Select a set of logically appropriate images for filling empty places.









97 Select logically appropriate set of images to fill the blank places of following arrangement.







CflilOlifliJl 'ffi'l1T (SPACE FOR ROUGH WORK A 23 J07

98 A family consists of D and C as its members. C has two sons, an unmarried daughter and a daughter-in-law and his wife shares all his responsibilities. H and his mother D are very supportive to wife in her social work. H is the brother-in-law of above mentioned daughter-in-law. sister assists wife E in her social work. Select option that indicates daughter.

G

P

E

H

99 Select the appropriate o,ption for replacing the question mark. jW10I QJ IZl31 yl2 All Al2 Bll









100 Choose appropriate alternative to replace the question marks?

G,17 I,14 15 None of the above 00­ Cfliql41ial 'l!T1TT /SPACE FOR ROUGH WORK P.T.O. J07 24 A -(1f6O 1 fcIfu"a forfut;: qr W "it m 3lWi, ml "l:IT'f0 q "r:maWloil d(g<ljAI( q <iMT '1i1(lqIAIi341 :mfiJT!f'i;qj ('1iili341 fum, 31f1lTrTA fcIfu"a t"AA tiq<"l11d( it 'JITU'lffi 3lWi. lffir llfta;rr "Ilo'lIl{cff Of fcR:mrr"Q«f 0fi1lIT am. Pick out the correct word to fill in the blank '11. Sl'. 201. I congratulate you your grand success. for

at

on •

about 1;11 6iTl: on" ml 3lWi. "ll itfc;, Sl'. 201 3lWi. '11. Sl'. 201. 3rnT U'fClT t<la5Hli<l1 i1Ji&lRnl 1Fcl<1' CIiTOOllT &lilli@Sl jSPACE FOR ROUGH WORK