Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
M. Pharm- SEMESTER I • EXAMINATION SUMMER -2018
Subject Code: 910203 Date: 07/05/2018
Subject Name: Advances in Pharmacology
Time: 02:30PM TO 05:30PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

What is DOTS? Give recent trends in the treatment of tuberculosis.
06

Write mechanism of action, pharmacokinetic and therapeutic uses of Azithromycin.
05

Explain the role of immunosuppressant's in organ transplantations giving suitable examples.
05
Q.2

Explain bacterial resistance to antimicrobials.
06

Give advances for the treatment of superficial fungal infections.
05

Discuss pharmacological actions of adrenaline.
05
Q.3

Discuss recent trends and developments in the treatment of malaria.
06

Classify α adrenoceptor antagonists. Describe pharmacology of prazosin.
05

Write a note on Co-trimoxazole.
05
Q.4

Write signal transduction mechanism and therapeutic implication of
drugs acting through muscarinic receptor subtype.
06

Discuss pharmacology of neuromuscular blockers.
05

Classify cephalosporins. Write the difference among them according to
pharmacokinetic properties and therapeutic uses.
05
Q.5

What is tumor? Differentiate benign tumor and cancer. Enlist the remedies for
preventing side effects of cancer chemotherapy and radiation therapy.
06

Discuss clinical uses and side effects of atropine.
05

Write on clinical applications of eicosanoids giving suitable examples.
05
Q. 6

What are HAART regimen? Write a note on zidovudine.
06

Give difference between sympathomimetics and parasymapathomimetics.
05

Explain mechanisms for the therapeutic action and adverse effects of
chloramphenicol.
05
Q.7

Discuss the current approaches in the management of sexually transmitted disease.
06

Discuss the role of 5-HT in pharmacology and give therapeutic applications of 5-HT receptor antagonists.
05

Name antimicrobial agents producing side effects
Ototoxicity Cinchonism Crystlluria Fanconi like syndrome
Orange red coloration in urine
05