Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm SEMESTER-V • EXAMINATION SUMMER 2017
Subject Code: 2250004 Date: 08/06/2017
Subject Name: Pharmaceutical Chemistry VII (Medicinal Chemistry-I)
Time: 10:30 AM to 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

What is Medicinal Chemistry? Give importance of Medicinal chemist in drug
development.
06

What is bioisosterism? Explain in detail with examples.
05

How stereochemistry affects biological action of drugs.
05
Q.2

Write a note on Partition coefficient and Ionization that affect biological activity.
06

Write a short note on Antitussives.
05

Write Chemical name and synthesis of Salbutamol and diatriazoic acid.
05
Q.3

What is asthma? Explain antiasthmatics in detail.
06

Give a note on radiological contrast media.
05

Discuss chemistry and biosynthesis of histamine.
05
Q.4

Give SAR of antihistaminic agents.
06

Give chemical name and synthesis of diphenhydramine and cetrizine.
05

Explain eicosanoids approved for human clinical use.
05
Q.5

What are proton pumps Inhibitors? Explain its mechanism of action. Give Synthesis of Omeprazole.
06

Write a note on Prokinetics and laxatives.
05

Write a note on Antiemetics and antidiarrheals.
05
Q. 6

Give SAR of cholineesters (Parasympathomimetics).
06

Write a note on Neuromuscular Junction blockers.
05

Classify Muscarinic antagonists with suitable examples.
05
Q.7

Write SAR of β-Phenylethanolamine.
06

Give Chemical name and synthesis of Dicyclomine HCl and Atenolol
05

Write a note on β-blockers.
05