Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM.-SEMESTER-VI- EXAMINATION -SUMMER-2017
Subject Code: 260003 Date: 03/05/2017
Subject Name: Pharmaceutical chemistry-VII (Biochemistry)
Time: 10.30 AM To 01.30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

How cholesterol biosynthesis is regulated? Give a brief note on degradation of cholesterol and important products formed.
06

Give a note on β-oxidation of fatty acids with energetic.
05

Give a note on Krebs-Henseleit cycle and its integration with the TCA cycle.
05
Q.2

Discuss formation of bile pigments from appropriate porphyrin.
06

Explain the components of electron transport chain. Give an account on the agents that inhibit ETC.
05

Give a short note: In vitro Polymerase Chain reactions.
05
Q.3

Define oxidative phosphorylation and explain with mechanism.
06

Explain: Icterus.
05

Write a short note on genetic code.
05
Q.4

Explain the types of DNA mutation along with its repair mechanisms.
06

Explain activation and utilization of methionine.
05

Explain in detail about the enzyme involved in biological oxidation.
05
Q.5

Define and explain the following: Hyperammonemia Non protein nitrogen transamination reaction of amino acids.
06

Explain about inhibitors of oxidative phosphorylation.
05

Give a note on water turn oven and balance.
05
Q. 6

Give detail note about protein biosynthesis in eukaryotes.
06

Write a note of centrifugation and chromatography in biochemistry.
05

Write a note on ketogenesis with its importance.
05
Q.7

Write a note on DNA replication.
06

Explain: Osteoporosis DNA vaccines
05

Explain in detail Lactose operon concept.
05