Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm SEMESTER-IV • EXAMINATION SUMMER-2017
Subject Code: 2240003 Date: 09/05/2017
Subject Name: PHARMACEUTICAL CHEMISTRY-V (BIOCHEMISTRY-II)
Time: 02:30 PM to 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Define and classify Proteins. Describe the α-helical structure of Protein.
06

Describe in brief the Urea Cycle.
05

Write a note on metabolism of sulphur containing amino acids.
05
Q.2

What are porphyrin? Write a note on its biosynthesis.
06

Describe the steps involved in formation of bile pigments.
05

Write a note on metabolism of purines.
05
Q.3

Write a note on damage and repair of DNA.
06

Describe in brief polymerase chain reactions.
05

Explain regulation of gene expression.
05
Q.4

Define oxidative phosphorylation. Discuss inhibitors of oxidative phosphorylation.
06

Describe the enzymes involved in biological oxidation.
05

Write a note on ETC.
05
Q.5

Describe the extraction and purification of protein and nucleic acids.
06

What is the use of spectrophotometry in biochemistry?
05

Write a note on different chromatographic techniques used in biochemistry.
05
Q. 6

Write a detailed account on Lac Operon Concept.
06

Describe in detail transamination and deamination reactions for amino acids.
05

Explain the pyrimidine biosynthesis with its regulation.
05
Q.7

Write a note on Metabolism of Phenylalanine.
06

Explain the genetic code with its characteristics.
05

Describe the Watson and Crick Model of DNA Structure.
05