Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm SEMESTER-V • EXAMINATION SUMMER-2017
Subject Code: 250004 Date: 08/06/2017
Subject Name: PHARMACEUTICAL CHEMISTRY-VI (MEDICINAL)
Time: 10:30 AM to 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Enumerate and define physicochemical properties of drug molecules. Explain Ionization and Hydrogen bonding in detail.
06

Explain in detail about Furguson's Principal.
05

Write in detail about biososterism.
05
Q.2

Give structure of following drugs:
Omeprazole Salbutamol promethazine Cyproheptadine
Ranitidine
06

Write a note on respiratory stimulants.
05

Write a detail note on Antitussive agents.
05
Q.3

Define expectorants, mucolytics and decongestants. Explain expectorants in detail
06

Write a note on antiemetic agents.
05

Describe biosynthesis of prostaglandins in detail.
05
Q.4

Give the synthesis and reaction of pyrrole and pyridine.
06

Write a note on Diagnostic agents.
05

Give synthesis of following drugs
Omeprazole diphenhydramine
05
Q.5

Justify following sentences.
1. Pyridine has higher basicity than pyrrole.
2. Thiophene is more aromatic than furan and pyrrole.
3. Pyrrole gives electrophilic aromatic substitution at second and fifth position.
06

Classify antisecretory agents in detail.
05

Write a note on Prokinetic agents
05
Q. 6

Explain the following with reaction mechanism
Hantch synthesis Fischer synthesis
06

Describe geometric and optical isomers in detail.
05

Write in detail about antidiarrhoeal agent?
05
Q.7

What are autocoids? Classify classical antihistamine with structure and add a note on histamine receptors
06

Explain about laxatives in detail
05

Write a note on antacids
05