B.Pharmacy 4/4 I-Semester (Supplementary) Examination
Subject Bio Pharmaceutics and Pharmacokinetics
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Define drug absorption. Explain various physicochemical factors influencing
absorption.
OR
What is the role of pH partition theory in absorption of drugs from GIT? Discuss in
detail the effects of drug pKa and pH on absorption.
Write a note on active transport mechanism of drug absorption.
2 Give an account of types and kinetics of protein binding of drugs, significance of
protein binding of disposition of drugs in body and factors affecting plasma protein
binding.
OR
Describe affect of various physiological barriers on distribution of drugs.
Write about displacement interactions in drug-protein binding.
3 Discuss with suitable examples the phase-I and phase-II reactions of drug
metabolism.
OR
Discuss various factors affecting biotransformation of drugs with suitable
examples.
Write short notes on first pass metabolism of drugs.
4 Derive pharmacokinetic parameters, plasma elimination half life and apparent
volume of distribution in biological systems
Write in brief about organ clearance.
OR
Explain the methods of determining AUC.
Discuss general approaches for dose adjustment in renal disease.
5 What are compartment models? Derive on expressions volume of assumptions,
limitations for drug administered by IV Bolus administration (one compartment
open model).
OR
Plasma samples from a patient were collected after an oral dose of 100mg of a
new drug as follows:
Time 1 2 3 4 5 6 8 10 12 14
Plasma concentration 0.38 0.73 0.91 0.97 0.97 0.92 0.71 0.53 0.40 0.30
Calculate pharmacokinetic parameters elimination rate constant, elimination half life
absorption rate constant and apparent volume of distribution, assuming one
compartment open model and first order drug absorption, along with plasma drug-time
graph.