FACULTY OF PHARMACY
B.Pharmacy IV/IV I Semester (Non-CBCS) (Main) Examination, November 2018
Subject: Bio-Pharmaceutics Pharmacokinetics
Time: 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1. Explain the theories of dissolution. 7
Explain in detail about carrier mediated transport. 7
OR
Explain the biological factors affecting the drug absorption. 7
Write a note on passive diffusion. 7
2. Explain the kinetics of Protein drug binding. 7
Write a note on passive diffusion. 7
OR
Explain the Organ/Tissue size and perfusion rate affecting distribution of drugs. 7
Describe about the physiological barriers to the distribution of drugs. 7
3. Explain phase I and phase II reactions with suitable examples. 14
OR
Explain the mechanism of renal excretion of drugs. 7
Explain about the concept of clearance.
4. Explain the zero order and First order kinetics. 7
Explain the methods of dose adjustment in patients with hepatic failure. 7
OR
Explain about pharmacokinetic parameters Apparent volume of distribution, half
life and clearance. 7
Explain drug drug interactions with suitable examples. 7
5. How do you obtain different pharmacokinetic parameters following intravenous
bolus administration of a drug that confers one compartment open model
characteristics. 14
OR
Plasma samples were collected from a patient after an oral dose of
benzodiazepine solution as follows. 14
Time
0.25 0.5 0.75 1.0 2.0 4.0 6.0 10.0 14.0 20.0
Plasma
Concentration

2.85 5.43 7.75 9.84 16.2 22.15 23.01 19.09 13.9 7.79
Calculate all possible pharmacokinetic parameters.