FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2016
POSSESSION USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.
BIOCHEMISTRY
PAPER I
BIO/D/16/03/I
Time 3 hours
Max. Marks 100
Important instructions:
• Attempt all questions in order.
• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.
• Start the answer to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. Write the step(s) with the reaction(s) used in the in-vitro synthesis of a
peptide having sequence 'ala-cys-glu'.
10
2. Classify glycerolipids.
Structure, functions and clinical significance of glycerolipids.

3. List five heteropolysaccharides.
Mention their structures and diseases associated with their defective
metabolism.

4. Define prenatal fetal screening of diseases.
List biochemical test(s) performed for fetal screening.
Mention how those tests are interpreted?

5. How are glomerular, tubular and endocrine functions of kidney assessed
by biochemical investigation(s)?
How is adequacy of hemodialysis assessed by laboratory tests?
6+4
6. Define and write the use(s) of:
Abzymes.
Isoform of enzymes.
Isoenzymes.
Ribozymes.
2.5x4
7. List the Westgard rejection rules. Add a note on 'external quality control'.
7+3
8. How is reference range of a laboratory parameter established?
Define diagnostic window of laboratory parameter. Compare diagnostic
window of CK-MB and myoglobin for acute myocardial infarction.
5+5
9. Define 'null hypothesis'.
List the test(s) of comparison used to reject null hypothesis.
What does value' signify?

10. How is correlation analysis performed for a nonparametric data?
Compare and contrast 'correlation analysis' with 'regression analysis'.
6+4