FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
JUNE 2018

POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.
PATHOLOGY
PAPER-I
PATH/J/18/32/I
Time: 3 hours
Max. Marks:100
Important Instructions:
Attempt all questions in order.
Each question carries 10 marks.
Read the question carefully and answer to the point neatly and legibly.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space
Answer all the parts of a single question together.
Start the answer to a question on a fresh page or leave adequate space between two answers.
Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:

1. Oxidative stress in cell injury.
Role of macrophages in chronic inflammation.
5+5
2. Micro-RNA and its role in diagnostic pathology.
Diseases caused by protein misfolding
5+5
3. Epigenetic changes in cancer.
Mechanism by which tumour evade immune system.
5+5
4. Polymorphonuclear function defects.
Mechanisms of T cell mediated hypersensitivity reactions.
5+5
5. Components of extracellular matrix.
Pathology of tertiary syphilis.
5+5
6. Reasons of dreadful pathogenicity of Plasmodium falciparum.
Mechanism of host resistance in malaria
Pathological spectrum of Leishmaniasis

7. Applications of Next Generation Sequencing.
RNA analysis in tumour biology.
5+5
8. Pathological findings and spectrum of disease in Ig G4
Related disease.
Mechanism of transformation of Stem cell like properties of
cancer cells.
5+5
9. Importance of calibration in clinical laboratory.
Immune mechanism in SLE
5+5
10. Leptin
Diet and cancer
5+5