Ph.D. Course Work Examination Jan/Feb-2018
CHEMISTRY (Paper III)
Modern Topics In Organic Chemistry
Day Date: Thursday, 18-01-2018
Max. Marks: 100
Time: 11.00 AM to 02.00 PM
Instructions: All questions are compulsory.
Q.1

Discuss Schmidt reaction with its mechanism. Give its application.
10

Answer Any Two:
10
Give the mechanism of Hoben-Hoesch reaction in the synthesis of;
trihydroxy acetophenone; dimethyl-5- acetyl pyrrole.
Write an account of Witting reaction.
Formulate the mechanism of Jones oxidation.
Q.2

Describe application of Suzuki reaction in C-C bond formation.
10

Answer Any Two:
10
Write the product and mechanism in the following:
Describe how the following transformation could be achieved?
Describe oxidation of alkenes with suitable example.
Q.3

How are the following protected? Give their mechanism.
10
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SLR-P-73

Answer Any Two:
10
Plan the synthesis of the following TM from the given starting material:
Carryout the retrosynthetic analysis of the following and suggest useful synthetic route:
Using retrosynthetic analysis suggests the synthetic route for the following molecule:
Q.4

Give the synthesis of Grignard's reagent. Describe its applications in organic synthesis.
10

Answer Any Two:
10
What are role of Anti-metabolites in treatment of cancer.
Explain Azidothyamidine derivatives as Anti-AIDS agents.
What are hypoglycaemic agents? Give SAR of sulphonamyl urea and biguinides.
Q.5

How Organo-Silicon compounds are prepared? Describe their utility in organic synthesis.
10

Answer Any Two:
10
What are Merriified resins? Discuss its uses in organic synthesis.
Explain synthetic uses of Baker's yeast.
What is PTC? Describes its applications in organic synthesis.