M.Phil Ph.D. Course Work Examination June July 2017
CHEMISTRY (Paper III)
Modern Topics In Organic Chemistry
Day Date: Thursday, 29-06-2017 Max. Marks: 100
Time: 11.00 AM to 02.00 PM
Instructions: All questions are compulsory.
Q.1 Discuss Sommelet reaction with mechanism. Give its applications. 10
Answer Any Two: 2X5
Give the mechanism of Knoevenagel reaction in the synthesis
of unsaturated acid.
Write an account of Wolff-Kishner reduction.
Formulate the mechanism of Photoreduction.
Q.2 Describe application of Heck reaction in C-C bond formation. 10
Answer Any Two: 2X5
Write the product and mechanism in the following:
Describe how the following transformation could be achieved?
Describe Pechmann reaction with suitable example.
Q.3 How are the following protected? Give their mechanism. 10
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SLR-OP-73
Answer Any Two: 2X5
Plan the synthesis of the following TM from the given starting
material:
Carryout the retrosynthetic analysis of the following and
suggest useful synthetic route:
Using retrosyntetic analysis suggests the synthetic route for the
following molecule:
Q.4 Give the synthesis of sodium borohydride. Describe its
applications in organic synthesis.
10
Answer Any Two: 2X5
Give recent development in the treatment of AIDS.
Explain the use of Taxol as Anti-AIDS agents.
Give synthesis and SAR of ampicilin.
Q.5 How organotin compounds are prepared? Describe their utility in
organic synthesis.
10
Answer Any Two: 2X5
Explain stereochemistry of fused bicyclic compounds.
What are uses of periodic acid and periodate in organic
synthesis.
Describes applications metal carbonyl in organic synthesis.