M.Sc. (Semester III) (CBCS) Examination Oct/Nov-2017
Genetics
INDUSTRIAL BIOTECHNOLOGY AND BIOINFORMATICS
Day Date: Saturday, 25-11-2017 Max. Marks: 70
Time: 02.30 PM to 05.00 PM
Instructions: Section I is compulsory.
Answer any four questions from Section II.
Section I
Q.1 Multiple choice questions. 07
A fed batch process is a system.
Closed Continuous
Intermittently fed Biphasic
Raw material rich in nitrogen source is
Sulphite waste liquor Molasses
Soya bean meal Malt extract
Up to the production of desired fermentation product, the process is
called process.
Upstream Downstream
Surface None of these
In database proteins are grouped into hierarchies of classes,
folds, super families and families.
PDB CATH
SCOP None
BLOSUM matrices are used for
Multiple sequence alignment Pair wise sequence alignment
Phylogenetic analysis All of these
Which is data retrieving tool?
Entrez EMBL
PHD All of these
All are sequence alignment tools except
BLAST FASTA
Clustal W Rasmol
Define the following terms: 07
IMRAD
3-D structure of protein
Downstream processing
Ultrasonication
Flocculation
Molecular modeling
Force field
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Section II
Q.2 Describe different types of Continuous bioreactors in detail. 14
Q.3 Take an account of Filtration and Centrifugation methods in downstream
processing.
14
Q.4 Write on different physical and chemical methods for treatment of effluents. 14
Q.5 Answer any two of the following: 14
Discuss in brief Nucleic acid sequence databases: Gen Bank, EMBL.
Give details of Primary Protein sequence databases: PIR, Swiss- PROT.
Explain Structural databases: PDB, MMDB.
Q.6 Write short notes on any TWO of the following. 14
Methods of Phylogenetic analysis.
Ramachandran Plot
Molecular dynamics simulations