M.Sc. (Semester III) (CBCS) Examination Oct/Nov-2017
Organic Chemistry
Drugs and Heterocycles
Day Date: Saturday, 25-11-2017 Max. Marks: 70
Time: 02.30 PM to 05.00 PM
Instructions: Section I is compulsory.
Attempt in all 5 questions.
Attempt any two questions from Section-II and any two from Section-III.
Answer to all questions (Section-I,II and III) should be written in the one
answer book.
All questions carry equal marks.
Figures to the right indicate full marks.
Section I
Q.1 Define the pharmaceutical terms of following: 07
Analgesics and antipyretics
Tranqculizers
Antibiotics
Functional drugs
Antihistamines
Sarcoma
Sedatives
Predict the product(s) of the following reactions: 07
Section II
Q.2 What are antimalarials? Describe the synthesis and mechanism of action of
trimethoprim.
07
What are anti-neoplastic drugs? Explain synthesis and mechanism of action
of melphalan.
07
Q.3 Explain the synthetic methods of Amoxycillin and their uses. 07
What are anti-Inflammatory drugs? Discuss the synthesis and mechanism
of action of Ibu-profen.
07
Q.4 What are analgesic and antipyretics? Give the synthesis and mechanism of
action of Meperidine.
07
Write notes on any two of the following: 07
Benadryl
Dapsone
Methyldopa
Section II
Q.5 What is Indole? Give the various synthetic methods of Indole denivatives. 05
Suggest the preparative route to aziridine involving nudeophilic
displacement reactions. Explain the ring opening reactions of aziridine
05
Chemical reactions of benzothiophene. 04
Q.6 Gives the synthesis and chemical reactions of thiazoles. 05
Explain the synthesis of oxazole derivatives from acylamino ketenes,
esters and amides with suitable mechanism.
05
Give the various synthetic methods of Inidazoles with mechanism. 04
Q.6 Write notes on any three of the following heterocycles: 14
Quinalines
Purines
Counmarins
Triazines