M.Sc. (Semester III) Examination Nov/Dec-2018
ORGANIC CHEMISTRY
DRUGS AND HETEROCYCLES
Time: 2½ Hours Max. Marks: 70
Instructions: Attempt in all 5 questions.
Questions 1 is compulsory.
All the questions carry equal marks.
Figures to the right indicate full marks.
Q.1 Multiple choice questions: Choose the correct answers of the
following
07
Antibiotic is a chemical substance produced from
Living cells Organisms
Penicillium Chrysogenum Fungus
2 Which is the species of plasmodium commonly infected humans as
malaria due to very high fever within few days
Plasmodium Malaria Plasmodium vivax
P. Falciparum P. Ovale
3 The drugs which bring body temperature to the normal temperature in
pyrexia condition are known as
Anti inflammatory Analgesic
Antipyretics Anesthetics
4 The drugs which are used to reduce inflammation and pain arising
from it are known as agents.
Analgesic Antipyretics
Anti-Inflammatory Inflammatory
5 T. B is a systematic infections disease caused by
Mycobacterium tubercle Mycobacterium bovis
Plasmodium vivax Mycobacterium leprae
6 The effective anti-leprotic drugs are
Streptomycin Isoniazide
Ethambutol Dapsone
7 The nonvolatile general anesthetic drug is
Isoquinoline Thiopental
Cyclopropane Cocaine
Predict the product of the following reactions. 07
Q.2 Answer the following (any four) 08
Fischer Indole synthesis.
Ring opening reactions of Aziridine by H2O ii) HCl
Synthesis of oxirane by using peracids.
Chemical reactions of 2-amina- pyridine with NBS and Nitrating
mixture.
Synthesis of quinoline from Aniline and ii) 3 dicarbonyl
compounds.
Write notes on (any two) 06
Synthesis of Coumarins from Resorcinol and ortho-hydroxyl
benzaldehyde.
Synthesis of Imidazoles
Chemical reactions of Thiazole
Q.3 Answer the following (any two) 08
How will you synthesize the Chromones from
Ortho-hydroxy aryl alkyl ketenes
ii) Ortho-hydroxy alkynyl ketenes
Chemical Reactions of Pyrimidines.
Synthesis of pyrazoles from 3 dicarbonyl compounds and
chalcones.
Answer the following (any one) 06
What are Quinazoline? Explain the synthesis and chemical reactions of
Quinazoline.
What are Pyrazines? Explain their synthesis and chemical reactions.
Q.4 Answer the following (any two) 10
What are -Lactum Antibiotics? Describe the synthesis, uses and
adverse effect of Ampicillin.
What are anti-Malaria drugs? Explain the synthesis, mechanism of
action applications of Trimethoprim.
What are Methadone and Isomethadone? Describe the synthesis,
mechanism of actions and application of Methadone and
Isomethadone.
Page 3 of 3
SLR-VW-7
Answer the following (any one) 04
Synthesis, mechanism of Action of Indomethacin.
What is DDS? Give synthesis and mechanism of action of DDS.

Q.5 Answer the following (any two) 14
What are General and Local Anaesthetics? Explain the synthesis,
mechanism of action, applications and adverse effect of
Procaine
ii) Thiopental
What are the Anti-histamines? Describe the synthesis, mechanism of
actions, applications and side effects of
Benadryl
ii) Phenobarbitone
What are the Tranquilizers? Explain the synthesis, mechanism of actions,
applications and adverse effects of
Diazepam
ii) Trimeprazine