M.Sc. DEGREE EXAMINATION, NOVEMBER 2017
Second Semester
Biochemistry
Elective MOLECULAR GENETICS
(CBCS 2014 onwards)
Time 3 Hours Maximum 75 Marks
Draw diagrams wherever necessary
Part A (10 x 2 20)
Answer all the questions.
1. Differentiate between leading strand and lagging strands.
2. What are Okazaki fragments? Why are the formed?
3. What is gene expression?
4. What is translation?
5. Differentiate between translation and transcription.
6. Define Linkage.
7. What is meant by transformation?
8. What are Transposons?
9. What is Polyploidy?
10. What are alleles?
Sub. Code
4MBC2E4
AFF-4938
2
Sp 5
Part B x 5 25)
Answer all the questions
11. Differentiate between Prokaryotic and Eukaryotic
transcription.
Or
Explain RNA types.
12. Comment on organization of genes within the
eukaryotic chromosomes.
Or
Distinguish between DNA denaturation and
renaturation kinetics.
13. Elaborate on DNA mismatch and excision repair
mechanisms.
Or
Give an account on construction of genetic maps
with two point test cross.
14. Explain exchange of genes in bacteria by the process
of transduction.
Or
Comment on the role of transposons in hybrid
dysgenesis.
15. What are holandric genes?
Or
What is the type of genetic inheritance of colour
blindness? Is colour blindness more frequent in men
or in women?
AFF-4938
3
Sp 5
Part C x 10 30)
Answer any three questions.
16. Give a comparative account on prokaryotic and
eukaryotic transcription.
17. Explain the mechanism of gene expression regulation in
Prokaryotes and eukaryotes.
18. Write an essay on gene mutations.
19. Explain in detail the mechanism of exchange of genes in
bacteria by conjuation and transformation.
20. Discuss in detail chromosomal rearrangements.
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