M.Sc. DEGREE EXAMINATION, APRIL 2018
Second Semester
Biochemistry
Elective MOLECULAR GENETICS
(CBCS 2017 onwards)
Time 3 Hours Maximum 75 Marks
Part A (10 X 2 20)
Answer all questions.
1. What is Pribnow box?
2. What is RNA turnover?
3. What is telomere? Mention its functions.
4. Differentiate lytic and lysogenic cycle.
5. A chromosome is 120 cM long. On the average, how many
Chiasmata will occur when it undergoes meiosis?
6. How does uv light produce revertible mutations?
7. What is Hfr conjugation?
8. What is transposase?
9. Define karyotype.
10. Mention the use of pedigree analysis.
Sub. Code
7MBC2E4
AFS-0719
2
WS3
Part B X 5 25)
Answer all questions, choosing either or
11. Enumerate the structural properties of DNA.
Or
Discuss the role of proteins involved in DNA
replication.
12. Present the experimental evidences for analyzing
the Kinetics of DNA renaturation.
Or
Explain the structure and functions of T4
bacteriophage.
13. Illustrate with suitable example the recombination
mapping with a three point test cross.
Or
Outline the types of gene mutation.
14. Explain the mapping of bacterial genes with
interrupted conjugation.
Or
Analyse the role of transposons in hybrid dysgenesis
of Drosophila.
15. Comment on genetic counseling.
Or
Write notes on chromosome rearrangements with
suitable examples.
AFS-0719
3
WS3
Part C X 10 30)
Answer any three questions.
16. Describe the mechanism of protein synthesis in
prokaryotes.
17. Discuss the Operon model for the regulation of gene
expression in bacteria.
18. Write an essay on the types of DNA repair mechanism.
19. Explain the steps involved in generalized transduction.
20. Elaborate with suitable examples the x-linked disorders
in human beings.
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