M.Sc. (Semester IV) (CBCS) Examination Mar/Apr-2018
Microbiology
PHARMACEUTICAL MICROBIOLOGY
Time: 2½ Hours
Max. Marks: 70
Instructions: Part- Questions No.1 Compulsory. Attempt any 4 questions from Part II. Figures to the right indicate full marks. Answer to the Part I and Part II are to be written in same answer booklet only.
Part I
Q.1
Choose the correct alternative given in the bracket.
14
Aminoglycoside antibiotic inhibits
Protein synthesis
Neuromuscular blockade
DNA gyrase susuceptability
Not good oral absorption but high first pass metabolism
Rifampicin inhibits the growth of
Hepatic microsomal enzymes
DNA synthesis
Mycobacteria
RNA synthesis
Broad spectrum antibiotics are developed through
Erythromycins
Cephalosporin
Tetracyclines
Penicillin
Glassware used to measure 24 hrs urine volume is a
Volumetric flask
Beaker
Graduated flask
Safety bulb
reagent is not routinely used to preserve tissues.
Formic acid
Zenkers fluid
Bouins fluid
10% formalin
Penicillin is a
Primary metabolite
Secondary metabolite
Tertiary metabolite
None of these
do not inhibit nucleic acid synthesis.
Norfloxacillin
Chloramphenicol
Trimethoprim
Rifampicin
Vancomycin is
Excreted by glomerular filtration
Inhibit protein synthesis
Is well absorbed from GTI
None of these
rapidly inhibit the incorporate of thymine into macromolecules of sensitive cells.
Chloramphenicol
Penicillin
Rifamycin
Ciprofloxacin
Page 2 of 2
SLR-UQ-548
10) is not used in Pseudomonas infections.
Cefoperazone
Imipenem
Penicillin
Gentamycin
11) Macrolide antibiotics
Are not used except for serious infection
Inhibit the 50s ribosomal subunit
Are bactericidal
Are inactivated by beta-lactamases
12) The best medium for the production of penicillin is
Sulfate waste liquor
Nutrient agar
Corn steep liquor
Whey
13) is a second generation cephalosporin.
Cefaclor
Ceflazidime
Cepholexin
Cefotaxime
14) is not semisynthetic penicillin.
Procain penicillin
Ampicillin
Cloxacillin
Carbenicillin
Part II
Answer any four questions from the following.
Q.2
What are antifungal antibiotics? Discuss in detail mode of action.
14
Q.3
Explain in detail aminoglycosides antibiotics with mechanism of action.
14
Q.4
Describe in detail Molecular Principles of drug targeting and add a note drug delivery system in gene therapy.
14
Q.5
Write in short on any Two of the following:
14
What is Immobilization? Explain with procedures for pharmaceutical industry.
What is Good manufacturing Practices Explain its importance in pharmaceutical industry.
Describe briefly Quality assurance and quality management in pharmaceutical industry.
Q.6
Write short notes on any Two of the following:
14
Explain in detail application of microbial enzymes in pharmaceuticals.
Define biosensors. Explain its application in pharmaceutical industry.
Describe in detail action of antibiotics on protein synthesis.