M.Sc. (Semester IV) (CBCS) Examination Nov/Dec-2018
Microbiology
PHARMACEUTICAL MICROBIOLOGY
Time: 2½ Hours Max. Marks: 70
Instructions: Part Question 1 is compulsory.
Attempt any 4 questions from Part II.
Figures to the right indicate full marks.
Answer to the Part I and Part II are to be written in same answer booklet
only.
Part I
Q.1 Rewrite the sentence by choosing correct alternative from the following: 14
Tetanus vaccine is a
Live vaccine Inactivated vaccine
DNA vaccine Toxoid vaccine
Bacteria get resistance for aminoglycosides by
Change in number and character of porin
Alteration of target site
Modifying enzymes
Degrading enzymes
Chloramphenicol
Does not penetrate the blood brain barrier
Can cause depression of bone marrow function
Can be safely used in premature infants
Must be administered parenterally
are antimicrobial agents that are applied to non living objects to
destroy microorganisms.
Disinfectants Antiseptics
Antibiotics Sanitizers
The commonly used gas for sterilization process in
Methane Hydrogen sulphide
Nitrogen Ethylene oxide
is not true.
Hydrophobic drugs have low solubility in water
Hydrophobic drugs are easily wetted
Hydrophobic drugs dissolve slowly
Drugs can be hydrophobic or hydrophilic
The target of antibiotic is topoisomerase enzyme.
Aminoglycosides Quinolones
Fosfomycins Beta lactams
radiation uses longer wavelength and lower energy for sterilization.
Non ionizing X ray
Gamma Ionizing
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SLR-VP-449
is not the mechanism of antibiotic resistance in bacteria.
Alteration in structure of target site
Modification of enzymes
Enzymatic degradation
Structural modification of antibiotic
10) The role of is to protect the integrity and quality of manufactured
product intended for human use.
Good record practices Good human practices
Good laboratory practices Good manufacturing process
11) is not the example of antiseptic agent.
Alcohols Acetic acid
Chlorine Quaternary ammonium compounds
12) is not an antifungal antibiotic.
Vancomycin Ketoconazole
Amphotericin Fluconazole
13) Varicella injection is a type of injection.
Intravenous Subcutaneous
Oral Intramuscular
14) department has responsibility and authority to approve or reject all
procedures and aspects of testing manufacturing.
Quality assurance Quality maintenance
Quality control R and D
Part II
Attempt any four questions from the following
Q.2 Describe in detail different mechanisms by which bacteria can become resistant
to antibiotics.
14
Q.3 Give a detailed account on disinfectants, antiseptics and Preservatives. 14
Q.4 Discuss in brief, how should be the design and layout of sterile product
manufacturing unit in pharmaceutical industrials.
14
Q.5 Write in short any two 14
What are the roles and responsibilities of quality control department in pharma
industry.
Describe in detail action of antibiotics on bacterial cell wall synthesis.
Comment on Drug targeting.
Q.6 Write short notes on any two 14
GMP and GLP
Drug carriers
Application of microbial enzymes in pharmaceutical industries