M.Sc. (Semester III) Examination Nov/Dec-2018
Biotechnology
ADVANCED PHARMACEUTICALS
Time: 2½ Hours Max. Marks: 70
Instructions: All questions are compulsory.
Figures to right indicate full marks.
Q.1 Multiple choice questions 14
Particle size is determined by
Gas Chromatography Cascade impactor
Light scatter decay Both b c
property measures the resistance of a liquid to flow.
Density Viscosity
Volume Solubility
is the correct definition of a pseudoplastic liquid.
A liquid which becomes less viscous as the rate of shear increases
A liquid which becomes more viscous as the rate of shear increases
A liquid which becomes less viscous over time when a constant shear
stress is applied
A liquid which becomes more viscous over time when a constant shear
stress is applied
is the correct definition of solubility.
The ability of solid particles to disperse throughout a liquid continuous
phase
The ability of a solute to dissolve into a solvent
The rate at which a solute dissolves into a solvent
The ability of immiscible liquid droplets to disperse within a second liquid
phase
of the following excipients may be used to limit the presences of
microorganisms in a liquid formulation.
Purified water Sodium Lauryl sulphate
Benzalkonium Chloride Ascorbic acid
is the role of xanthan gum within some liquid formulations.
Regulate pH Control viscosity
Enhance solubility Enhance Stability
of the following liquid dosage forms requires a sterile formulation.
Eye drops Spray applied to skin
Shampoo Oral syrup
The filling method of a pharmaceutical liquid depends on the
following factors.
Viscosity of the liquid
Surface tension of the liquid
Compatibility with the materials used in the construction of the filling
machine
All the above
Page 2 of 3
SLR-VW-25
To increase the viscosity of liquid of the following agents are used.
PVP Cellulose
Sodium Carboxy CMC
10) surfactants will facilitate or aid wetting of hydrophobic materials in
liquid.
By decreasing the solid liquid interfacial tension
By increasing the solid liquid interfacial tension
Both
Decreasing surface tension
11) The stability of suspensions can be evaluated by
Sedimentation volume Dissolution
Dispersion Precipitation
12) The temperature at which the inversion occurs depends on emulsifier
concentration is known as
Temperature Humidity
Phase inversion temperature Freezing
13) of the following mechanical equipment can be used for
emulsification.
Homogenizers Glass bead
Centrifugation Shaking
14) of the following is not used as a emulsifying agent.
Surfactant Hydrophilic colloids
Electrolytes Finely divided solids
Q.2 Answer the following (any four) 08
Binary Mixture
Granules
Dosage
Micelle
Polymer
Write note on (any two) 06
Surfactants
Polyethylene
Kinetics
Q.3 Answer the following (any two) 08
Types of Polymers
Physical testing of the drugs
Effect of dissolution of drugs
Answer the following (any one) 06
Solid dispersions
Particle Characterization
Q.4 Answer the following (any two) 10
Define Dissolution? Explain the Dissolution test apparatus.
Antibacterial activity.
Methods of Polymerization reactions
Answer the following (any one) 04
Stability studies of the drug
Lubricant sensitivity