B.Sc. (Part ii) (Semester iV) (Biotechnology) (New CBCS)
Examination, 2018
Mechanisms in Imunology
Day and Date Tuesday, 8-5-2018 Max. Marks 70
Time 10.30 a.m. to 1.00 p.m.
Instructions All questions are compulsory.
Figures to the right side indicates full marks.
1. Rewrite the following sentences by choosing the correct alternative
given below 14
In cell mediated immunity will perform role in target cell killing.
Perforans Fragmentins
Granzymes All of these
ii) In the B blood group person type of isoantibodies
are present.
Anti-A Anti-B
Anti-AB Anti-D
iii) is non-organ specific autoimmune disease.
Myasthenia gravis Systemic lupus erythromatosus
Graves disease Pernicious anemia
iv) B cells are matured in
Bone marrow Spleen
Thymu's Lymph node
is primary mediator of anaphylaxis.
Platelet activating factor Prostaglandins
Leukotrienes All of these
vi) will be used for fusion of B lymphocytes and myeloma cells
in monoclonal antibody synthesis technique.
PEG HAT
HGPRT Ig
vii) Exogenous antigen is presented to T cells by molecule.
MHC II MHC III
MHC I None of these
viii) Transfer of antibodies from mother to baby is called as
immunization.
Natural passive
Artificial passive
Natural active
None of these
ix) Blood group antigens were discovered by
Landsteiner Burnett
Marrack Darwin
Lysozyme is present in body fluids.
Saliva Sweat
Cerebrospinal fluid Urine
xi) Primary immune response is characterized by the production of
type of antibodies.
IgM IgD
IgG IgA
xii) complement component contains unstable thioester bond
undergo spontaneous hydrolysis in alternate pathaway.
C1 C2
C3 C4
xiii) Erythroblastosis fetalis, hemolytic disease of newborn is caused
by hypersensitivity.
Type I Type II
Type III Type IV
xiv) discovered hybridoma technique for monoclonal antibody
production.
Robert Koch
Burnett
Kohler and Milestein
Marrack
2. Answer any seven (out of nine) of the following 14
Complement components.
ii) Define antibody and give its types.
iii) Inflammation.
iv) Define hypersensitivity.
Define autoimmunity.
vi) Functions of B cells.
vii) Hemolytic diseases.
viii) NK cells.
ix) Innate and acquired immunity.
3. Answer any two (out of three) of the following 10
Chemical barriers of innate immunity.
ii) Primary and secondary immune response.
iii) Explain any two non-organ specific autoimmune diseases.
Explain ABO and Rh blood group system. 4
4. Answer any two of the following 14
Explain processing and presentation of endogenous antigen.
ii) Explain traditional vaccines with example.
iii) Explain General mechanism of autoimmunity (any 4 mechanism).
5. Answer any two of the following 14
Explain T cell maturation, activation and differentiation.
ii) Explain alternate complement pathway.
iii) Monoclonal antibody synthesis and its application.