B.Sc. (Part II) (Semester IV) Examination, 2018
Biotechnology (New CBCS)
Mechanisms in Immunology
Day and Date Wednesday, 12-12-2018 Total Marks 70
Time 10.30 a.m. to 1.00 p.m.
Instructions All questions are compulsory.
Figures to the right indicate full marks.
1. Rewrite the following sentences by choosing the correct alternative given below. 14
Eyelens protein is an example of
Hidden antigen Isoantigen
Hapten None of these
ii) BCG is an example of vaccine.
Live attenuated Subunit
Killed Conjugate
iii) is organ specific autoimmune disease.
Myasthenia gravis Systemic lupus erythrematosus
Graves disease None of these
iv) T cells are matured in
Bone marrow Spleen
Thymus Lymph node
is primary mediator of anaphylaxis.
Histamine Prostaglandins
Leukotrienes Platelet activating factor
vi) glycoprotein acts as antiviral agents that inhibit intracellular viral replication.
Lysozyme Interferon
Fibronectin Lactoferrin
Seat
N
o.
Set
P
P.T.O.
vii) Endogenous antigen is presented to T cells by molecule.
MHC II MHC III
MHC I None of these
viii) Blood group antigens were present on
Neutrophils Eosinophils
Basophils Monocytes
ix) Lysozyme is present in body fluids.
Saliva Sweat
Cerebrospinal fluid Urine
Clonal selection theory of antibody production was proposed by
Landsteiner Burnett
Marrack Darwin
xi) Secondary immune response is characterized by the production of type of antibodies.
IgM IgD
IgG IgA
xii) Passive immunization is done by using
Vaccines Toxoids
Immune sera Toxins
xiii) antibody predominantly present in mucosa.
IgM IgD
IgG IgA
xiv) hybridoma technique for monoclonal antibody production.
Robert Koch Burnett
Kohler and Milstein Marrack
2. Answer any seven (out of nine) of the following 14
Function of complement components.
ii) Define antibody and give its types.
iii) Phagocytosis.
SLR-SJ 31 *SLRSJ31*
Set P
iv) Define atopy and anaphylaxis.
Define autoimmunity and hypersensitivity.
vi) Functions of TH and Tc cells.
vii) Hemolytic diseases.
viii) NK cells.
ix) Factors affecting innate immunity.
3. Answer any two (out of three) of the following 10
Physical barriers of innate immunity.
ii) Give difference between primary and secondary immune response.
iii) Explain any two organ specific autoimmune diseases.
Explain ABO blood group system. 4
4. Answer any two of the following 14
Explain processing and presentation of exogenous antigen.
ii) Explain New trend vaccines with example.
iii) Explain General mechanism of autoimmunity (any 4 mechanism).
5. Answer any two of the following 14
Explain B cell maturation, activation and differentiation.
ii) Explain classical complement pathway.
iii) Cellular mechanism of innate immunity.