M.Sc. (Semester (CBCS) Examination Nov/Dec-2018
Bioinformatics
BASIC BIOINFORMATICS
Time: 2½ Hours Max. Marks: 70
Instructions: All questions are compulsory.
Q.1 Multiple choice Questions:- 14
database is a Microarray gene expression database studying in
bioinformatics.
GEO MMDB
DDBJ EMBL
is a graphical control element that presents a hierarchical
view of information of phylogentic analysis.
Diagonal view Alignment view
Tree view Domain view
The delta rule is often utilized by the most common class of ANNs called
neural networks.
classification backpropagational
unidirectional feed forward
Clustal w is a multiple alignment program available either as
a stand-alone or on-line program.
exhaustive block based
progressive iterative
is branch of which study the organismal variation in phenotype as
it changes during its life span.
Phenomics Metabolomics
Transcriptomics Genomics
database only contains sequence families not covered in Pfam-A.
Prosite PIR
pfam b Blocks
Markov model describes the probability of the current state being
determined by the previous state.
First-order Second-order
Third-order Zero-order
is molecular biology database and text data along with sequence
data retrieval system developed by NCBI.
Dbget dblink
Entrez Srs
is a database that uses multiple alignments derived from the most
conserved, ungapped regions of homologous protein sequences.
Emotif Blocks
Smart Cath
10) In a protein sequence alignment, refers to the percentage of
matches of the same amino acid residues between two aligned sequences.
sequence identity sequence homology
sequence similarity sequence non homology
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SLR-VC-47
11) alignment does not assume that the two sequences in question
have similarity over the entire length.
Local Global
Heuristic Clustal
12) The is a global network of computer networks that links
government, academic and business information.
FTP Gmail
Telenet Internet
13) The scoring systems is called a which is derived from statistical
analysis of residue substitution data from sets of reliable alignments of highly
related sequences.
substitution matrix sequence alignment
sequence identity sequence homology
14) The term sequence which is the similar at same position of same
amino acid along with similar in physiochemical properties such as size,
charge, and hydrophobicity.
identity similarity
homology xenology
Q.2 Answer any four of the following 08
What is interactomics?
What is guide tree in phylogentics analysis?
What is sequence identity in string matching algorithm?
What is local alignment in sequence analysis?
What is BanKit in Genbank nucleotide sequence database?
write notes on (Any Two) 06
Write the steps of system biology in study of associated disciplines.
Explain the PAM scoring matrix in dynamic programming algorithm.
Explain the Entrez search engine in data mining.
Q.3 Answer the following (Any Two) 08
Explain ANN in bioinformatics for analysis the biological data.
Explain the BLAST tool at NCBI in details.
Explain the Protein Information resources sequence database.
Answer the following:- (Any One) 06
Explain multiple sequence alignment and its type in details.
Write in details about the application of neural network in bioinformatics.
Q.4 Answer the following (Any Two) 10
Explain the Phylip software Package in details.
Explain protein secondary sequence database in details.
Write the Gene array and analysis of gene array in bioinformatics in
details.
Answer the following:- (Any One) 04
Write EMBL nucleotide sequence database in details.
Explain the support vector machine in machine learning technique.
Q.5 Answer the following (Any Two) 14
Write in details note on HMM and HMM in bioinformatics analysis.
Explain the Genbank, EMBL, MSF biological sequence file format.
Explain the goals and scope and application of bioinformatics.