M.Sc. (Semester (CBCS) Examination Nov/Dec-2018
Biotechnology
BIOSTATISTICS AND BIOINFORMATICS
Time: 2½ Hours Max. Marks: 70
Instructions: All questions are compulsory.
Figures to the right indicate full marks.
Q.1 Multiple choice questions:- 14
The phylogenic lineage evolving with the same speed from common ancestor
called
Lock Key Evolution
Mutation Molecular clock
of the following is not a measure of central tendency.
Mean Mode
Range Median
method is based on an experimentally determined structures
which are closely related on sequence level.
Fold recognition Homology modeling
Threading Ab intio
The middle value of an ordered array of numbers is the
Mean Median
Mode Midpoint
was established in 1984 by National biomedical research foundation.
PIR Swiss Prot
OWL MIPSx
A circle divided into sectors proportional to the frequency of items shown is
called
Bar hart Pie chart
Histogram Polygon
is a unix program for molecular dynamic simulation for protein
structure.
Clustal Phylip
PAUP Gromacs
Considering probability distribution, if mode is greater than median the
distribution is classified as
Variable model Constant model
Left skewed Right skewed
method of BLAST is queries nucleotide database with nucleotide
sequence.
Blastp Tblastn
Blastn Blastx
10) Arranging values in columns is called
Matrix Graph
Cells Tabulation
Page 2 of 2
SLR-VE-73
11) is method at PDBsum for analysis of protein three dimensional
structures.
Procheck Dali
Prosite Emotif
12) is the fundamental statistical indicator.
Median Variance
Standard Deviation Variable
13) is a graphical way of comparing two sequences in two dimensional
matrix methods.
Dynamic Dot plot
Clustering Progressive
14) Distribution which has outliers with relatively lower values is considered as

Negatively skewed Experimentally skewed
Exploratory skewed None of these
Q.2 Answer the following any four:-
What is primary structure of protein?
Define population.
What is sequence homology?
Define linear regression.
What is Global alignment?
08
Write notes on any
Explain the molecular docking methods.
Write a note on Frequency Distribution.
Add a note on hypothesis testing.
06
Q.3 Answer the following. (Any Two)
Explain the functions of NCBI.
Add a note on skewness and kurtosis.
Write in detail about the steps of homology modeling.
08
Answer the following. (Any One)
Explain the secondary database of proteins.
Describe in detail measure of dispersion.
06
Q.4 Answer the following. (Any Two)
Explain the protein secondary structure prediction methods.
Write a note on correlation and regression.
Add a note on Multiple sequence alignment.
08
Answer the following. (Any One)
Explain the merits and demerits of Chi-square test.
Write a note on molecular mechanics.
06
Q.5 Answer the following. (Any Two) 14
Write in detail about the Nucleic acid sequence database.
Explain the molecular modeling and its packages in detail.
Calculate mean deviation for the following data:-
9.2 9.6 10 11 12 9.8 10.2 9.9 12.7 10.6