DISTANCE EDUCATION
M.Sc. (Chemistry) DEGREE EXAMINATION, MAY 2018.
ORGANIC CHEMISTRY I
(2008 onwards)
Time Three hours Maximum 100 marks
Answer any FIVE questions.
All questions carry equal marks.
× 20 100)
1. What are the criteria for aromaticity?
Explain why p-nitro benzoic acid is stronger
than m-nitro benzoic acid?
What are the products obtained when nitro
benzene and toluene are nitrated?
Give an example for alternant and nonalternant
hydrocarbon.
Account the following:
Cyclo octatetraene fails to exhibit aromatic
character.
Tropolone does not form an oxime.
Discuss the effect of hydrogen bonding on the
dissociation constant of acids.
Explain any two non-kinetic methods of
determination of reaction mechanism.
Sub. Code
11
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2. What is the electrophilic attacking reagent in
aromatic nitration? Give the mechanism of nitration
of benzene.
What are hard and soft acids? Give one
example for each.
What is the catalyst used in the Friedel
Craft alkylation and acylation reaction?
Explain its role in the above reaction.
Write down SN1 mechanism and discuss the solvent
and substrate effects.
3. Hydroboration is a regiospecific reaction Explain.

What are the methods employed to detect hydrogen
bonding?
Write short note on competition between
elimination and substitution reactions.
What is the stereochemistry of pyrolytic
elimination? Explain.
Benzaldehyde undergoes Cannizaro's reaction
whereas acetaldehyde undergoes aldol
condensation reaction Explain.
Write a note on Benzyne mechanism.
4. How would you elucidate the structure of
5. Elucidate the structure of oxytocin.
What are enzymes? What are their characteristics?

Distinguish between and amylopectine.

6. How would you synthesis the following compounds
Anthocyanin Oxazole
Outline the synthesis of atropine.
Discuss the end group analysis of peptides.
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7. Write any two annulenes and comment on their aromaticity.
How can the stereochemistry of the products be
used to predict the mechanism of aliphatic
nucleophilic substitution reaction? Give any two examples.
Explain the stability of carbonium ions.
Discuss the mechanism of the following reactions
knoevenagal reaction Michael addition.
8. Discuss the primary, secondary and tertiary structure of proteins.
Distinguish between DNA and RNA.
Write down the functions of oxytocine.
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