Answer any three of the following. Each question carries 10 marks.

1. Briefly describe the complement system and its various pathways.

2. Define and classify vaccines. Add a short note on BCG vaccine.

3. Define and classify antigen-antibody reactions. Add a note on the VDRL test.

4. Define the various types of hypersensitivity reactions. Write a short note on immediate hypersensitivity reaction.

5. Write short notes on any four of the following:

Widal Test

Tetanus Toxoid

ELISA

Autoimmune Reactions

Mantoux Test

6. Write briefly about the following

Incomplete antigen

Antistreptolysin o

Definition and example of autoimmunity

Precipitation Tests

Immunofluorescence

7. Write True or False against the following statements:

Anaphylactic shock is an example of delayed (Type-IV) hypersensitivity.

DPT vaccine protects against diphtheria, polio and typhoid.

HIV targets CD4 T-lymphocytes.

Eosinophils are increased in parasitic infections.

B-lymphocytes are chiefly involved in cell mediated immunity.

8. Fill in the blanks from the choices provided.

An example of an innate immune component is

Natural killer cells

Plasma cells

SDS-PAGE stands for

Sodium dodecyl sulphate polyacrylamide gel electrophoresis

Synthetically derived soluble particle gradient electrophoresis

Genetically programmed death of autoreactive T-lymphocytes in thymus is via

apoptosis

necrosis

antibodies are capable of crossing the placenta to reach the fetus.

IgG

IgM

Neutrophils kill invading bacteria by

secreting antibodies directed against them

oxidative burst of H202 and free radicals