Exam Details
| Subject | drug design and molecular pharmacology (262913) | |
| Paper | ||
| Exam / Course | m.pharm. | |
| Department | ||
| Organization | Dr.M.G.R. Medical University | |
| Position | ||
| Exam Date | May, 2019 | |
| City, State | tamil nadu, chennai |
Question Paper
THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[LO 352] MAY 2019 Sub. Code: 2913
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV PHARMACOLOGY
PAPER IV DRUG DESIGN AND MOLECULAR PHARMACOLOGY
Q.P. Code 262913
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Describe in detail about the role of selected physicochemical properties in relation
to drug action and drug design.
2. Explain the principle, procedure and methods used in Recombinant DNA
technology. Add a note on its application.
II. Write notes on: (10 x 6 60)
1. Hydrogen bonding and surface actions.
2. What are the disease targets for gene therapy?
3. Explain receptor polymorphism and its importance.
4. Discuss about the ionization.
5. Explain the combinatorial chemistry.
6. Explain lead seeking methods in drug design. Give its significance.
7. What are QSAR models?
8. Describe briefly about High throughput screening.
9. Explain Hansch equation.
10. What are the advantages and disadvantages of natural products and lead
compounds?
[LO 352] MAY 2019 Sub. Code: 2913
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV PHARMACOLOGY
PAPER IV DRUG DESIGN AND MOLECULAR PHARMACOLOGY
Q.P. Code 262913
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Describe in detail about the role of selected physicochemical properties in relation
to drug action and drug design.
2. Explain the principle, procedure and methods used in Recombinant DNA
technology. Add a note on its application.
II. Write notes on: (10 x 6 60)
1. Hydrogen bonding and surface actions.
2. What are the disease targets for gene therapy?
3. Explain receptor polymorphism and its importance.
4. Discuss about the ionization.
5. Explain the combinatorial chemistry.
6. Explain lead seeking methods in drug design. Give its significance.
7. What are QSAR models?
8. Describe briefly about High throughput screening.
9. Explain Hansch equation.
10. What are the advantages and disadvantages of natural products and lead
compounds?
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