THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[LO 351] MAY 2019 Sub. Code: 2912
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV PHARMACOLOGY
PAPER III BIOLOGICAL STANDARDISATION AND PHARMACOLOGICAL
SCREENING METHODS
Q.P. Code 262912
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Describe in detail the different in vivo models employed in the screening of antiarrhythmic
drugs.
2. In vitro and In vivo models used for screening anticancer drugs.
II. Write notes on: (10 x 6 60)
1. Various methods of breeding of laboratory animals.
2. Screening methods for drugs used in Parkinsons disease.
3. Preparation and maintenance of cell lines.
4. General principles of immunoassays.
5. Role of transgenic animal models in preclinical research.
6. Euthanasia.
7. Paired test and student test.
8. Conditioned avoidance test.
9. Acute toxicity studies.
10. Models used in drug absorption studies.