THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[LO 342] MAY 2019 Sub. Code: 2903
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I PHARMACEUTICS
PAPER III BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code 262903
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Explain two compartment open model. Derive suitable equations for calculating
pharmacokinetic parameters for extra vascular administration of drug that follows
two compartment open model.
2. Explain principal involved in renal excretion of drug with suitable example.
Describe drug binding in tissues.
II. Write notes on: (10 x 6 60)
1. GCP guidelines for bio equivalence studies.
2. Loading dose, maintenance dose and accumulation index.
3. Explain any two Phase II reactions.
4. Non Renal excretion of drugs.
5. Explain passive transport and facilitated diffusion.
6. Measurement of bio availability.
7. Non linear Pharmacokinetics.
8. Factors affecting bio transformation of drugs.
9. Non compartmental models.
10. Drug distribution in body fluids.