THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[LO 804] MAY 2019 Sub. Code: 3804
PHARM. D DEGREE EXAMINATION
(2009-2010 Regulation)
FIRST YEAR
PAPER IV PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code 383804
Time Three hours Maximum 70 Marks
I. Elaborate on: x 10 40)
1. Explain the Aliphatic nucleophilic substitution with mechanisms and kinetics
involved in the reactions.
2. Explain the mechanisms of following name reactions:
Benzoin condensation. Wittig reaction.
3. Explain the activating and deactivating and M directing groups in the
aromatic compounds.
4. Give an account of acid and base on the basis of Lewis theory and Lowry-
Bronsted concept.
II. Write notes on: x 5 30)
1. Preparation, tests for purity, assay and uses of aspirin.
2. Explain the reaction mechanisms of Sandmeyer's reduction with suitable
examples.
3. Explain fries rearrangement and Hofmann rearrangement.
4. Add a note on Isomerism.
5. What are cycloalkanes? Give example. How the cycloalkanes are prepared?
6. Polarity of bond and Aprotic solvents.