[LO 114] MAY 2019 Sub. Code: 2011
M.D. DEGREE EXAMINATION
BRANCH III PATHOLOGY
PAPER II GENERAL PATHOLOGY
Q.P. Code: 202011
Time 3 Hours Maximum 100 Marks
I. Essay: x 15 30)
1. Enumerate the Lysosomal storage diseases. Discuss the pathogenesis of
Lysosomal storage diseases. Write about Niemann-Pick disease.
2. Write about Immunologic deficiency syndromes. Discuss about the
Primary Immunodeficiencies and Describe X-linked Agammaglobulinemia
of Bruton.
II. Write short notes on: (10 x 5 50)
1. Gaucher disease.
2. Anaphylatoxins.
3. Thermal injury.
4. Sudden infant death syndrome.
5. Cell cycle.
6. Fat embolism.
7. Rickets.
8. Heat shock proteins.
9. Growth factors in wound healing.
10. Karyotyping techniques.
III. Reasoning Out: x 5 20)
1. A 26 year old women with third degree burns developed septic shock.
Within 24 hours she was bleeding from all needle puncture sites, with
extensive ecchymoses, petechiae and gastro intestinal bleeding. Lab
studies showed Hb-6gm/dl, platelet count 64000/cu mm, PT 20 seconds,
PTT 50 seconds and D-dimer positive. Discuss the pathology of this
condition.
2. A known patient of HIV developed multiple lymph nodes and abnormal
peripheral smear findings. What is the complication involved? What is the
lymph node morphology?
3. A 45 year old lady gave birth to a baby with flat facial profile, oblique
palpebral fissures and epicanthic folds. What is the probable diagnosis?
Discuss the genetic aspects and clinical features.
4. 1 month old child presented with intestinal obstruction due to meconium
ileus and prolonged neonatal jaundice. Mother of the child said her infant
tastes salty. What is your diagnosis? What is the genetic defect in this
condition? What is the morphology of various organs?

[LO 114]