Master of Science II (Organic Chemistry)
Examination: Oct Nov 2016 Semester III (Old CGPA)
SLR No. Day
Date Time Subject Name Paper No. Seat No.
SLR SD
178
Wednesday
23/11/2016
02:30 PM
To
05:00 PM
Drugs and Heterocycles
C
XII
Instructions: Answer any five questions.
Section- I (question one) is compulsory.
Attempt any two questions from section- II and
Any two questions from section- III.
Answer to all five questions (from Section-I, II,III)
should be written in the one and the same answer book.
All the questions carry equal marks.
Figures to the right indicate full mark.
Total Marks:70
SECTION I
Q.1 Draw the correct structure of following drugs: 07
6-APA
Chloroquine
Aminoprine
Fenediazole
Quinidine
6-Mercaptopurine
Cephalosporin
Predict the product(s) of following reactions: 07
Page 1 of 2
SECTION-II
Q.2 What are antibiotics? Give the synthesis and uses of following antibiotics:
Ampiciline Cephalexin
07
What are antimalarials? Discuss the synthesis and mechanism of action for
Trimethoprim.
07
Q.3 Explain the different synthesis methods of procaine and mechanism of
nerve impulse transmission in action of local anaesthetics.
07
What is histamine? Explain synthesis and mechanism of action of Benadryl
antihistamine?
07
Q.4 What are cardiovascular drugs? Give the synthesis of oxypernolol and
Diltiazem cardiovascular drugs.
07
Discuss the synthesis and applications of following anti-inflammatory drugs
(any
Ibuprofen Oxyphenbutazone Dichlorophenac
07
SECTION-III
Q.5 Explain the cyclization of open chain to oziridine ring is stereospecific.
What is the action of following on aziridine?
HCL Vinyl Cloride
05
Explain ring opening of oxetane by nucleophiles is slower than that of
oxirane. What is the action of following on oxetane?
HCL CH3COCl Lewis acid
05
Explain Fisher-Indole synthesis by using suitable example with mechanism. 04
Q.6 Discuss the different synthesis methods of imidazole with mechanism. 05
Give synthesis of oxazole derivatives and explain why electrophilic
substitution reaction should occur in the and position.
05
What are purins? Give synthesis and chemical reactions of purins. 04
Q.7 Write short notes on any three of the following heterocycles. 14
Pyridazines
Pyrimidines
Quinoxalines
Coumarins