1 'Xerogel' refers to

Hydrogel

Dehydrated gel

Gel containing organic solvent

Excess water in gel

2 Formula to relate doses for children to their age as per Young's rule is given by

Age in years Age in years 20 Proportion of adult dose

Age in years/20 Proportion of adult dose

Age in years/12 =Proportion of adult dose

Age in years/Age in years 12 Proportion of adult dose

3 Drugs with low therapeutic index have to be cautiously administered since

their median toxic dose is high

they are very potent and have low dose

difference between effective and toxic levels is less

None of the above

4 The concentration of dextrose isotonic with blood plasma is

0·9% w/v

4·5% w/v

w/v

0·45% w/v

5 Which of the following is commonly not used for packaging by pharmacists for filling a prescription

Blister pack

Prescription bottles

Sifter top containers

Dropper bottles

6 Which of drugs? the following is not a method for enhancing transdermal permeation of

Iontophoresis

Sonophoresis

Electrophoresis

Hydration of skin

7 When hypotonic solution is injected intravenously it leads to

Shrinkage of RBCs

Haemolysis of RBCs

Neither shrinkage nor haemolysis

and

8 A physician requests a 0·1% steroidal cream that is commercially available as a 0·25% strength in a vanishing cream base. Which one of the following ointment bases is the best choice as a diluent in this situation?

Hydrophilic ointment

Vaseline

Lanolin

Cold cream

9 What does Schedule W of Drugs and Cosmetics Act 1940 and Rules 1945 contain

List of drugs which shall be marketed under generic name only

Life period of drugs

Standards for cosmetics

Biological and special products

10 What does DTAB abbreviate for?

Drugs Technology Advisory Board

Directorate of Technological Advisory Board

Directorate of Technical Advisory Board

Drugs Technical Advisory Board

11 Aqueous coating systems for water insoluble polymers are commonly prepared in the form of

solubilized systems by means of surfactant addition

solutions with the aid of cosolvents

pseudolatex systems which are colloidal dispersions

None of the above

12 Computer base PMRs are used for maintaining

Patient Medication Records

Prescriptions of Prescriber

Adverse Drug Reaction

Inventory Control

13 Pyrogens which cause a rise in body temperature when injected intravenously are structurally

Bacterial phospholipids

Bacterial lipopolysaccharides

Viral DNA

Bacterial glycosides

14 As per Schedule A of Drugs and Cosmetics Act 1940 and Rules 1945, Form 19-B is for

Application for licence to sell, stock or exhibit or offer for sale or distribute Homoeopathic medicines

Licence to manufacture for sale or for distribution of Homoeopathic medicines

Licence to manufacture for sale or for distribution of drugs other than those specified in Schedule X

Certificate of renewal of licence to sell, stock or exhibit or offer ,for sale or distribute Homoeopathic medicines

15 The degree of flocculation of a suspension is expressed as

Ratio of volume of flocculated sediment to total volume of suspension

Ratio of total volume of suspension to volume of flocculated sediment

Ratio of sedimentation volume of flocculated suspension to the sedimentation volume of the suspension when deflocculated

Sediment volume of flocculated suspension

16 Capping in tablets occurs due to

Defective dies and punches

Damp granules

Excessive fines

and

17 Toxicity at normal doses of Isoniazid is likely to be due to

Age

Generic factor

Disease state

Renal function

18 The Drugs Price Control Order is passed under

Essential Commodities Act

Drugs and Cosmetics Act

Pharmacy Act

Control of Prices Act

19 An adverse reaction relatively specific ·to the use of antibiotics belonging to the class of aminoglycosides is

Ototoxicity

Occular toxicity

Hepatotoxicity

Aplastic anaemia

20 Which of the following is a non-absorbable suture?

Cat gut

Reconstituted collagen

Polyamide

Kangaroo tendon

21 Tolerance to one kind of drug that results in tolerance to a pharmacologically similar drug is known as

Synergistic dependence

Reciprocity

Tolerance threshold

Cross tolerance

22 An extension of the normal pharmacological effect of a drug or its metabolite is termed as

Type C ADR

Type D ADR

Type A ADR

Type B ADR

23 While attending to patients during counselling sessions, the desirable body language should be
I. Facing the patient directly.
II. Leaning forward at a slight angle.
III. Nodding and hand gestures.
IV. Blank stares.

I and II

Only I

II and III

I and IV

24 A potentially life-threatening adverse drug effect may occur due to

Bronchoconstriction in asthamatics due to non-steroidal anti-inflammatory agents

Osteoporosis caused by steroids

Hirsutism induced by Minoxidil

Retinopathy caused by Thioridazine

25 Positive control in 'Test for Sterility' ensures

the sterility of all materials

the nutritive property of medium

the sterility of product

None of the above

26 As per I.P., for a batch size of 100 numbers (ampules, vials, etc.) of a parenteral product, minimum numbers recommended to be tested for sterility are


10% or 4 numbers, whichever is greater

10% or 6 numbers, whichever is greater

or 2 numbers, whichever is greater

or 3 numbers, whichever is greater

27 Addition of which of the following to a large volume parenteral product'is not advised?

Active pharmaceutical ingredient

Preservatives

Buffering agents

Tonicity adjusters

28 An ophthalmic solution of a mydriatic drug with a concentration of 5 mg/ml exhibits first-order degradation with a rate of 0·0005 mg/day. Estimate its half life.

693 days

1,200 days

210 days

1,386 days

29 Which microbe IS used for validation of sterilization by membrane filtration process?

Bacillus stearothermophilus

Pseudomonas aeruginosa

Serratia marcescens

Bacillus subtilis

30 Morphine sulphate comes under which Schedule of Drugs and Cosmetics Act

X

K

H

G

31 The dosage required to produce a desired pharmacological effect is called

Threshold dose

Dose-response outcome

Effective dose

Maximum dose


32 In form-fill-seal process the essential material used is

Aluminium

Polyacrylate

Paper-metal composite

Polyethylene

33 Sonication of liposomal product may be related to conversion of

MLV to ULV

SUV to MLV

MLV to SUV

None of the above

34 Which of the following plots would be most helpful III deciding shelf life at a predetermined temperature

Remaining undegraded vs time

Log remaining undegraded vs time

Log rate vs log absolute temperature

Log rate vs inverse of absolute temperature

35 Which of the following statements regarding polymorphs is true

Polymorphic forms of the same drug are similar and can be substituted in a formulation

Different polymorphic forms of the same drug have identical X-ray diffraction patterns

The metastable polymorphic forms will generally result in a higher dissolution rate

All of the above

36 A solution of 1 in 2500 strength means

0·04%

0·4%

0.25%

0·5%

37 Hixon and Crowell Cube-root law is related to

Micro emulsification

Drug dissolution

Stability of API against hydrolytic degradation

Sedimentation in liquids containing more than 10% suspended particles

38 The term 'hydrotrophy' is used to denote

water uptake capacity

water repulsion capacity

increase in aqueous solubility due to presence of large amounts of additives

wetting ability

39 Patients on tranylcypromine therapy are in danger of undergoing a hypertensive crisis on consumption of a cheese rich diet due to

Interaction of tranylcypromine with calcium in cheese

Inhibition of absorption of tranylcypromine by cheese

Presence of antioxidant in cheese

Tyramine content of cheese

40 An estimate of the water absorption capacity of 100 gms of material as 'water number' is a parameter for evaluation of

Hydrogels

Absorption bases

Gelling agents

Wetting agents

41 Autoclavable plasticware for repeated sterilization is best fabricated using

Low density polyethylene

Polystyrene

Polyvinyl chloride

Polypropylene

42 Scalpels and blades for surgery may be sterilized by

Boiling in a water bath

Membrane filtration

Dry heat sterilization

Aseptic technique

43 Which of the following is added as antioxidant in pharmaceutical dosage forms?

Sorbitan monooleate

Ascorbic acid

Methyl cellulose

Sodium saccharin

44 Shelf life of a pharmaceutical product is computed by

Ficks laws

Arrhenius equation

Higuchi equation

Noyes Whitney equation

45 As per Indian Pharmacopoeia MacConkey agar has

malachite green

bromocresol purple

neutral red

brilliant green

46 Bioavailability and pharmacokinetic data either is or may be required when pharmaceutical companies submit
I. New drug application
II. Abbreviated new drug application
III. Supplemental application

II and III

I and II only

III only

I only

47 Gastric emptying is slowed by all of the following, except

fatty food

emotional stress

vigorous exercise

hunger

48 A suspension is not a suitable dosage form for

intra muscular injection

intra venous injection

intra articular injection

intra dermal injection

49 Hypodermic needle sizes are expressed by gauge numbers. The gauge number refers to the

bevel size

internal diameter of the cannula

external diameter of the cannula

size of the lumen opening

50 330 mg of aspirin is to be filled in hard gelatin capsules. Which is the appropriate capsule size



2

0

00

51 The phase inversion temperature of a surfactant is one at which

surfactant forms micelles

surfactant melts

hydrophilic and lipophilic properties of surfactant are balanced

surfactant undergoes inversion

52 Irrespective of the source, principle constituent of absorbable catgut is

Cellulose

Fibrin

Collagen

Gelatin

53 Idiosyncratic reactions to drugs are

seen only in certain individuals

unrelated with dose of drug administered

often without explanation of cause

All of the above

54 What is the shelf life of eye drops immediately after opening?

30 days

90 days

14 days

7 days

55 In the hospitals, the records regarding purchase and distribution of 'controlled substances' are to be kept in prescribed format by

Store keeper

Pharmacist

Ward nurse

All of the above

56 In the test for sterility 'Fluid Thioglycolate Medium' is used for detection of

Aerobic bacteria

Fungi

Aerobic and anaerobic bacteria

Fungi and anaerobic bacteria

57 The words "It is dangerous to take this preparation except under medical supervision" can be found on label of drugs belonging to

Schedule X

Schedule H

Schedule C

Schedule G

58 Excipients that increase the aqueous solubility of poorly soluble drug are

Wetting agents

Solubilizers

Stabilizing agents

Dispersing agents

59 What should be the air velocity in a horizontal laminar flow work area?

50 ft/min

10 ft/min

200 ft/min

100 ft/min

60 How many grams of sodium chloride should be used in the preparation of 250 ml of Isotonic Dextrose and Saline solution containing 2·5% w/v of anhydrous dextrose?

4·5 gms

1·125 gms

2·5 gms

0·9 gms

61 Which of the following can aggravate pain in Prinzmetal variant angina?

Vasodilators

Calcium channel antagonists

blockers

None of the above

62 Antihypertensive found safer during pregnancy is

Reserpine

Propranolol

Losartan

Hydralazine

63 Hypolipidemic drug which produces its effect by inhibiting VLDL production is

Lovastatin

Nicotinic acid

Gemfibrozil

Fluvastatin

64 Dimercaprol is a therapeutic antidote against

Heavy metals poisoning

Opiate poisoning

Salicylate poisoning

Pesticide poisoning

65 Which measure is not used in methanol poisoning

Folate therapy

Sodium bicarbonate infusion

Ethanol administration

Disulfiram therapy

66 The drug used in the first line thera,py of tuberculosis is

Ethionamide

Ethambutol

Cycloserine

Clofazimine

67 The reactive electrophilic intermediate of Acetaminophen which produces hepatotoxicity is

N-acetyl-para-benzoquinonimine

N-acetyl-ortho-benzoquinonimine

N-methyl-ortho-benzoquinonimine

N-methyl-para-benzoquinonimine

68 The drug whose side effect has been exploited thromboembolic disorders is in the prophylactic treatment of

Indomethacin

Rofecoxib

Aspirin

Nimesulide

69 Isoniazid produces antimycobacterial action by

inhibiting DNA dependent RNA polymerase

preventing bacterial protein synthesis

inhibiting synthesis of mycolic acids

inhibiting mycobacterial arabinosyl transferases

70 Anti-HIV drug Saquinavir is

protease activator

nucleoside reverse transcriptase inhibitor

protease inhibitor

non-nucleoside reverse transcriptase inhibitor

71 Human immunodeficiency virus can be transmitted by the following routes

Blood transfusion

Placental transfer

Option and above

None of the above

72 Sucralfate is used in the treatment of

Hypertension

Allergy

Diabetes

Ulcers

73 Which of the following is systemic antacid

Sodium hydroxide

Aluminium hydroxide

Sodium bicarbonate

Magnesium salts

74 Cephalosporins produce their antibacterial activity by interfering with

Cell wall synthesis

Cell membrane functions

Ribosomal protein synthesis

Intermediary metabolic pathways

75 The non-sedating antihistaminic is

Terfenadine

Diphenylhydrazine

Meclizine

Mepyramine

76 Which of the following is a competitive antagonist of H2 receptors?

Chlorpheniramine



Promethazine

All of the above

77 Which of the following agents is not a pesticide?

Organophosphates

Pyrethroids

Aromatic hydrocarbons

Rotenone

78 Trazodone is used as

Antidepressant

Antidiabetic

Antiulcer

Cardiotonic

79 Shock, an acute cardiovascular syndrome, is associated with

Hypotension

Oliguria

Metabolic acidosis

All of the above

80 Beta blockers must be used with great caution in diabetic patients because

they mask the symptoms of hypoglycemia

they prevent the correction of hypoglycemia

Option and above

None of the above

81 Which of the following drugs Improves exercise tolerance in patients with effort induced angina?

Nicardipine

Metoprolol

Option and above

None of the above

82 Nephrotoxicity is common with

Cyclosporine

Gentamicin

Option and above

None of the above

83 Which of the following drugs helps reverse the muscle paralysis following cobra bite?

Pancuronium

d-tubocurare

Option and above

Edrophonium

84 Which of the following category of drugs is not used in the treatment of hypertension

Catecholamines

beta receptor antagonists

Potassium channel activators

Diuretics

85 Beta lactamase resistant penicillin is

Ampicillin

Piperacillin

Nafcillin

Ticarcillin

86 Which of the following drugs is employed as a 'Cardiotonic' in the treatment of congestive cardiac failure

Furosemide

Amphetamine

Spironolactone

Digoxin

87 The hallmark of HIV infection is

increase CD3 lymphocytes

increase CD4 lymphocytes

decrease CD4 lymphocytes

decrease CD3 lymphocytes

88 Diuretic which inhibits carbonic anhydrase enzyme is

Hydrochlorothiazide

Furosemide

Spironolactone

Acetazolamide

89 Which of the following is a narrow spectrum antibiotic?

Tetracycline

Ampicillin

Chloramphenicol

Penicillin G

90 The specific antidote used in morphine toxicity

Picrotoxin

Penicillamine

Naloxone

Nimesulide

91 The sub-class of pesticide Strychnine is

Rodenticide

Insecticide

Herbicide

Fungicide

92 What is the ratio of Sulfamethoxazole and Trimethoprim in Co-trimoxazole

1:20

20:1

1:1

20:20

93 Which of the following is a fourth generation Cephalosporin

Cefaclor

Cefotaxime

Cefepime

Cephalexin

94 A drug used in topical therapy of burns

Mafenide

Salicylic acid

Co-trimoxazole

Acyclovir

95 Which of the following is not a toxic effect of salicylates

Tinnitus

Gastric bleeding

Edema

Postural hypotension

96 Which of the following antibiotics does not act on the cell membrane

Amphotericin B

Nystatin

Polymyxins

Lincomycins

97 Plumbism is associated with toxicity due to

Lead

Mercury

Arsenic

Barbiturates

98 Concurrent ingestion of antacid with tetracycline

forms highly absorbable complex

forms poorly absorbable complex

enhances metabolism of tetracycline

has no effect on tetracycline

99 Non-peptide orally active angiotension-1 receptor antagonist is

Saralsin

Lisinopril

Losartan

Enalapril

100 The confirmatory test for positive ELISA used the screening of HIV infection is

PCR

RT-PCR

Northern blot

Western blot