Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
BPHARM SEMESTER II • EXAMINATION WINTER • 2016
Subject code: 220002 Date: 02-01-2017
Subject Name: Pharmaceutics-II
Time: 02:30 pm 05:30 pm Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Define size reduction. Explain different mechanisms, factors affecting and applications of size reduction.
06

Explain the principle, construction, working, advantages, limitations and applications of fluid energy mill with help of a neat sketch.
05

Explain the principle, construction, working, advantages, limitations and applications of ball mill with help of a neat sketch.
05
Q.2

Discuss the principle, construction, working, advantages, limitations and applications of Cyclone Separator with the help of a neat sketch.
06

Discuss Carr' Index, Hausner's ratio, Angle of repose with its significance.
05

Explain the principle, construction, working, advantages, limitations and applications of colloid mill with help of a neat sketch.
05
Q.3

Define and explain Mixing Mixing Index Degree of Mixing.
06

Explain the principle, construction, working, advantages, limitations and applications of planetary mixer with help of a neat sketch.
05

Explain the principle, construction, working, advantages, limitations and applications of sigma blade mixer with help of a neat sketch.
05
Q.4

Discuss the Mier's super saturation theory. What are its limitations?
06

Explain principle, construction, working, advantages and limitations of Swenson Walker crystallizer with the help of a diagram.
05

Define Crystal Lattice ii) Crystal Habit iii) Polymorphs iv) Crystal Solvates Amorphous Compounds.
05
Q.5

Explain Soxhlet extractor for continuous hot extraction with a neat and labelled diagram.
06

Write a note on solvents used for extraction.
05

Explain the principle, construction, working, advantages, limitations and applications of triple roller mill with help of a neat sketch.
05
Q. 6

Explain the effect of compressional force on powders/granules. Explain Kawakita equation and its use in compression.
06

Explain the theory of compaction and compression.
05

What is caking of crystals? What are the reasons behind it? Explain methods for prevention of caking of crystals.
05
Q.7

Explain the importance of measurement of temperature in the pharmaceutical industry. Enumerate different devices and explain any one.
06

Write brief note on fire extinguishers.
05

Write the importance and applications of crystallization in pharmaceutical industry.
05