Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
D.Ph. 2nd Year • EXAMINATION WINTER -2018
Subject Code:420003 Date:22/11/2018
Subject Name: Pharmacology and Toxicology
Time: 02:30 p.m. to 05:30 p.m. Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Explain the following terms:
Pharmacology Bioavailability Pharmacokinetic
Drug resistance Chemotherapy Toxicology
06

Enlist routes of drug administration. Explain merits and demerits of injectional route.
05

Write note on Plasma protein binding Drug antagonism
05
Q.2

Describe various factors affecting the absorption of drug.
06

Define general and local anesthetics. Classify general anesthetics. Enlist stages of general anesthesia.
05

Differentiate narcotic and non-narcotic analgesic. Explain mechanism of action of NSAIDs.
05
Q.3

Comment: Aspirin used as anti-platelet agent in small dose.
L-dopa is given in combination with carbidopa in Parkinson's disease.
Ethanol is used in treatment of methanol poisoning.
06

Define and classify sedative and hypnotic.
05

What is parasympatholytic? Describe therapeutic uses of atropine.
05
Q.4

Explain (1)Analeptic MAO inhibitor
06

Define diabetes mellitus. Classify oral hypoglycemic agents.
05

Write note on anti metabolite as anticancer agent.
05
Q.5

Explain Drug automatism Myasthenia gravis Co-trimoxazole
06

Define cardiotonic. Describe pharmacology of digitalis.
05

Classify anti tubercular agents. Write pharmacology of Rifampicin.
05
Q. 6

Explain Loop diuretic ACE inhibitors
06

Write notes on Dale's vasomotor reversal Leucotriene inhibitor
05

Describe circus movement and statins.
05
Q.7

Explain following term with examples:
Antacid Laxative Expectorant
06

Give therapeutic uses and adverse effects of chloramphenicol.
05

Describe mechanism of action and disadvantages of penicillin.
05