Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
Pharm D 3rd Year • EXAMINATION SUMMER 2019
Subject Code: 838802 Date: 08/05/2019
Subject Name: Pharmaceutical Analysis
Time: 02:30PM TO 05:30PM Total Marks: 70
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

What is meant by ICH guidelines? Enlist quality guidelines details.
06

Write a note on GLP.
04

Briefly explain process of total quality management and documentation in pharmaceutical Industry.
04
Q.2

Describe theory, instrumentation and applications of HPLC.
06

Describe detectors of Gas chromatography.
04

Explain: Types and application of paper chromatography.
04
Q.3

Describe theory, instrumentation and applications of HPTLC.
06

Explain principles of polarimeter and circular dichroism.
04

Explain principle of NMR and ESR.
04
Q.4

What is chemical shift? Describe the factors affecting chemical shift.
06

Give the principle of AES with its applications.
04

Discus various sample handling techniques in IR spectroscopy.
04
Q.5

Expalin the theory of fluorescence and phosphorescence. Discuss the factors affecting fluorescence intensity.
06

Define:
Potentiometry Rf value
Hypsochromic shift Beer-Lambert's law
04

Write a short note on flame photometer.
04
Q. 6

Give an account of the detectors used in UV VIS spectrophotometer. Add a note on monochromators.
06

Discuss the types of ions and their significance in MASS Spectra.
04

Explain theory of X-ray diffraction. Brief about reciprocal lattice concept.
04
Q.7

Note on detectors of IR spectroscopy.
06

Write a note on Hollow cathode lamp.
04

Define:
Wave number
Ilkovic's equation
Amperometric titrations
Diffusion current
04