Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: 2270004 Date: 22/11/2018
Subject Name: Pharmacology and Pharmacotherapeutics III
Time: 10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Classify antimicrobial agents and give disadvantages of combined antimicrobial agents therapy.
06

Explain the different mechanisms of resistance with examples.
05

Write a note on antifungals.
05
Q.2

Discuss the mechanism of (any five):
Griseofulvin Chloramphenicol Vancomycin Oseltamivir
Clavulanic acid Cotrimoxazole
10

What is DOTS? Write a short note on management of Tuberculosis.
06
Q.3

Classify cephalosporins. Explain their mechanism of action and adverse effects.
06

Explain in detail the pharmacology of Ciprofloxacin.
05

Discuss the pathophysiology and management of Enteric infection.
05
Q.4

Discuss the pathophysiology and treatment of Prostate Cancer.
06

Describe the complications and management of Hodgkin's Lymphoma.
05

Write a note on macrolides.
05
Q.5

Give the principle use and adverse effects of (any four):
Streptomycin Zidovudine Dapsone Acyclovir Tetracycline
10

Discuss the pathophysiology, prevention and management of Amoebiasis.
06
Q. 6

Classify anticancer drugs highlighting their mechanism of action.
06

Discuss the pathophysiology, complications and management of Leptospirosis.
05

Discuss the management of UTI.
05
Q.7

Comment:
Gray baby syndrome is a common adverse effect of Chloramphenicol.
Adrenaline is used in penicillin induced Anaphylaxis.
Pyridoxine is used concomitantly with Isoniazid.
06

Write a note on anthelmentics.
05

Outline the life cycle of Malarial parasite. Discuss the use of "Co-artemether".
05