Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: 2240005 Date: 30/11/2018
Subject Name: Basic Concepts of Pharmacology and Clinical Pharmacy Practice
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Enlist different types of G-proteins. Explain signal transduction mechanism in G-protein coupled receptors.
06

Enumerate different reactions involved in Biotransformation of drugs. Discuss phase II in detail.
05

Discuss the factors modifying drug action.
05
Q.2

Classify drug interactions. Discuss pharmacokinetic drug interactions with suitable examples.
06

List out the mechanisms involved in transport of drugs across biological membranes. Discuss the ABC transporters.
05

Enlist different types of ion channels with examples. Discuss gating mechanisms in brief.
05
Q.3

Explain the following with suitable examples wherever necessary(any three)
1. Tachyphylaxis 2. Inverse agonist 3. Spare receptors 4. Iatrogenic effects
06

Write a note on tolerance.
05

Highlight the physiological differences that necessitate changes in drug therapy in children and elderly.
05
Q.4

Classify the routes of drug administration. Write a note on transcutaneous route.
06

Explain bioavailability and bioequivalence. Write a note on biological half life.
05

Write a note on Pharmacovigilance.
05
Q.5

Describe the steps in a typical patient counseling session. List the communication skills required for effective counseling.
06

Discuss the criteria for TDM and its significance.
05

What are the causes for irrational drug use. Highlight the dangers of irrational use of antibiotics.
05
Q. 6

Discuss the various communication skills for effective patient counseling.
06

Classify ADRs as per Rawlins-Thompson system with suitable example.
05

What is essential drug list? Give the salient features of essential drugs?
05
Q.7

Write a note on (any four)
1. Volume of distribution
2. Drug antagonism
3. Medication errors
4. Loading and Maintenance dose
5. Medication adherence
16