Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm. SEMESTER- II • EXAMINATION WINTER -2018
Subject Code: 2220003 Date: 11/12/2018
Subject Name: Pharmaceutical Analysis-II
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Explain the principle, application and types of paper chromatography.
06

Write a short note on Thin Layer chromatography.
05

Briefly explain Retention mechanisms involved in chromatography.
05
Q.2

Comment on the following statements:
Potassium chloride is preferred in salt bridge.
ii) Conductance of HCl in non-polar solvent is higher than conductance of HCl in polar solvent.
iii) Separation efficiency is independent of number of plates.
06

Write a detailed note on Conductometric titrations.
05

Describe factor affecting conductance.
05
Q.3

What is emf. Classify electrode and what are the ideal characteristics of indicator electrode.
06

Discuss the applications of potentiometry.
05

Define Reference electrode. Enlist the types of it and write note on standard calomel.
05
Q.4

Describe principle, working and applications of Polarimetry.
06

Write a short note on Biamperometric titration.
05

Give difference between optically active and optically inactive compound.
05
Q.5

Describe instrumentation of TGA.
06

Discuss the advantages, disadvantages and limitation of instrumental method of analysis.
05

Explain the application of DSC in detail.
05
Q. 6

Define validation. Enlist parameters of analytical method validation and explain the source of noise in instrumental analysis.
06

Describe multiple extraction technique. How pH affect extractability of the drugs.
05

Discuss the theory of extraction.
05
Q.7

Write note on NPP and DPP.
06

What is stripping voltammetry? Explain in detail any two techniques.
05

Describe the oxygen combustion flask method.
05