Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: 250004 Date: 29/11/2018
Subject Name: Pharmaceutical Chemistry VI (Medicinal)
Time: 10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Explain the following with reaction mechanism:
Skraup synthesis b)Paal-Knorr synthesis
06

Give the structure of:
Pyran Triazole Isoquinoline Pyrazine Piperidine
05

Give TWO reactions of the following:
Imidazole b)Pyridine
05
Q.2

Comments on the following
Thiophene is more aromatic than furan
Pyridine is more basic than Pyrrole
Unionized drug is absorbed better than ionized drug
06

Give synthesis of Ranitidine Chlorpheniramine
05

Define expectorants and mucolytics. Explain expectorants in detail
05
Q.3

Discuss various Proton Pump Inhibitors
06

Describe various drugs used in irritable bowel syndrome
05

Classify antihistaminic agents and write a note on SAR of H1 receptor blockers
05
Q.4

Explain the effect of following parameter on biological activity.
Complexation
Hydrogen bonding
06

Write a note on Antitussive agents.
05

What are antiemetic agents? Classify them with examples
05
Q.5

Comment on following statements
Imidazole is less basic than pyrazole.
Indole is aromatic
Thiophene is more reactive for electrophilic substitution than furan
06

Explain Radiological contrast media.
05

What are eicosanoids? Write in brief about eicosanoid biosynthesis.
05
Q. 6

What is Bioisosterism? Classify and Explain in brief with examples.
06

Give synthesis and use of Promethazine and Chlorcyclizine.
05

Write a note on Diagnostic agents.
05
Q.7

Discuss Stereo chemical features of drug molecules influencing biological activity.
06

Write a note on geometric optical isomerism.
05

Explain Fischer-Indole synthesis with reaction mechanism.
05