Exam Details
Subject | drugs | |
Paper | ||
Exam / Course | ||
Department | ||
Organization | maharashtra public service commission | |
Position | assistant commissioner | |
Exam Date | 04, November, 2012 | |
City, State | maharashtra, |
Question Paper
1 What is true of affinity tags?
Affinity tags are long peptide sequences.
Affinity tags have 4 consecutive tyrosine residues.
Affinity tags have 6 consecutive histidine residues.
Affinity tags have 8 different amino acid residues.
2 Which anticoagulants are permitted to be used for storing whole Human Blood as per IP
Anticoagulant Citrate Dextrose solution
Anticoagulant Citrate Phosphate Dextrose solution (ACPD)
Low Molecular Weight Heparins (LMWHs)
Sodium Warfarin
and
and
and
and
3 Place the steps involved in hemostasis in the correct order of their occurrence:
Conversion of fibrinogen to fibrin
Conversion of prothrombin to thrombin
Activation of intrinsic or extrinsic pathway
Formation of prothrombinase.
and
and
and
and
4 What is the correct combination of temperature and duration of storage respectively for preservation of Cryoprecipitate?
-20°C for 6 months
-20°C for 9 months
-30°C for 9 months
-30°C for 12 months
5 What is the maximum volume of blood advised to be donated within consecutive period of 12 months
1.0 L
1.2 L
1.5 L
1.8 L
6 Which chemical is released by platelets when they adhere to the damaged wall
Histamine
5 -Hydroxytryptamine
Acetylcholine
Adrenalin
7 How many types of antigens have been detected on the surface of Red Blood Cells
Five
Ten
Fifty
More than one hundred
8 In which disease, Type -IV Hypersensitivity reaction causes chronic intestinal inflammation and obstruction?
Contact dermatitis
Rheumatoid arthritis
Crohn disease
Multiple sclerosis
9 What is not true of the Haemolytic disease of newborns?
It can affect malnourished newborns.
Causes jaundice.
Occurs because of incompatible blood transfusion in newborns.
Can be prevented by injecting the mother with anti agglutinins just after delivery.
and
and
and
and
10 When is HBIG administered to an infant born to HBs Ag positive mother?
Within 7 days after birth
Within 1 day after birth
Within 8 hours after birth
Within 12 hours after birth
11 What is not true of the composition of blood?
Plasma forms 91.5% of blood.
WBCs are largely responsible for the viscosity of blood.
Albumins form the major group of plasma proteins.
Macrophages are a type of circulating RBCs.
and
and
and
and
12 Which hemopoietic growth factor regulates conversion of myloid stem cells to myloblasts
Colony Forming Unit -Erythrocyte
Colony Forming Unit -Leukocyte
Colony Forming Unit -Granulocyte Macrophage
Colony Forming Unit -Erythropoietin
13 What is not true of the cord stem cells?
They are easily collected.
They are more in stem cells than in red bone marrow.
The match between donar and recipient has to be exact in a transplant.
Less likely to transmit infections.
and
14 What is not true of the intrinsic pathway of coagulation?
It is fast and simple.
Its activators are in direct contact with blood.
Outside tissue damage is not needed.
Contact with collagen fibres activates factor XII.
15 The following is true about anaphylactic reactions:
Occurs within a few minutes after exposure to allergen in a previously sensitised person.
IgE antibodies and mast cells play an important role
Rheumatoid Arthritis is an example.
Penicillin can cause it in a few people.
and
and
and
and
16 Which organism is known to cause Lymphogranuloma Venereum in both the sexes?
Neisseria gonorrhoeae
Trichomonas vaginalis
Treponema pallidium
Chlamydia trachomatis
17 What is true of the Genital Herpes?
It is not curable
It is recurrent
Caused by HSV
Chancres are produced in advanced stages.
and
and
and
and
18 How much minimum percent Haemoglobin content should whole Human Blood contain?
11.1
10.2
9.7
8.5
19 Which type of antibody causes anaphylaxis leading to vascular dilation and edema leading to inflammation
IgE
IgA
IgD
IgM
20 What is the chemical nature of antigens present on the surface of RBCs
Phospholipid
Glycolipid
Lipopoly saccharide
Glycoprotein
21 Which organ or its part is affected by ureaplasma urealyticum
Ureter
Urethra
Nephron
Glomerulus
22 Match the blood group with the colour scheme of the labels:
Column A Column B
(Blood group) (Label colour)
O Yellow
A White
B Blue
AB Pink
23 HIV mainly damages follOWing types of cells.
Halper T cells
Natural Killer Cells
Red blood cells
Eosinophils
24 Which of the following is/are activated by thromboplastin?
Fibrinolytic system
Extrinsic coagulation pathway
Platelet aggregation
Graft Vs host reaction
only
and
and
and
25 A hematocrit of 40 indicates the following:
Blood forms 40% of body fluids.
RBCs form 40% of the total volume of blood.
RBCs, WBCs and platelets together form 40% of the total volume of blood.
Haemoglobin is 40% lower than normal range.
26 Fill in the blank. Tissue type plasminogen activator that cleaves plasminogen to form plasmin is a enzyme.
Nuclease
Amylase
Protease
Lipase
27 What is the quantum of formed elements in whole blood?
40%
45%
55%
60%
28 Which are the two most important constituents of Fibrin sealant kit
Fibrinogen and thrombin
Prothrombin and thrombin
Fibrin and Fibrinogen
Vitamin K and thromboplastin
29 When did the Government of India publish National Blood Policy?
1950
1991
2002
2010
30 Which is the most common viral antigen found on the surface of HIV
P 24
P 12
P 3128
P 8080
31 What are the anti -viral drugs recommended for treatment of H1N1 viral infections?
Oseltamivir
Zanamivir
Acyclovir
Lamivudin
and
and
and
and
32 What drugs are used to terminate early pregnancy?
Finasteride
Tamoxifen
Clomiphene
Mifepristone
and
33 What is not true of oxytocin?
It acts through a protein coupled receptors.
Number of oxytocin receptors increc1se in late pregnancy.
It is used in uterine inertia.
Estrogens desensitize uterus to oxytocin.
and
and
34 What is the threshold limit value for chloroform at a workplace?
2 ppm
3 ppm
5 ppm
10 ppm
35 What is the main site of action for steroid hormones?
Cytoplasm
Plasma membrane
Nucleus
Mitochondria
36 In which of the following organs Fluoride and Lead get concentrated?
Body fat
Intravascular space
Extracellular space
Bones
37 Which of the following antiepileptic drugs acts as a GABA transaminse inhibitor?
Sodium valproate
Vigabatrin
Tiagabine
Gabapentine
38 Which of the following drugs is given during hypertensive emergencies as a IV infusion?
Nifedipine
Nitroglycerine
Sodium Nitroprusside
Propranolol
39 What is not true of the mechanism of action of local anaesthetics?
They block conduction of Na ions.
A resting nerve is very sensitive to its action.
Small unmyelinated C fibers are blocked before the larger fibers.
The drug enters the cell in charged form.
and
40 What is the duration of each cycle of non -rapid eye movement (NREM) sleep?
90 min
10 min
60 min
30 min
41 What is not true of primaquine?
It is not useful in treatment of symptomatic malaria.
It is used to eradicate the hypnozoites of P.vivax and P. ovale.
Used for prophylaxis in healthy travellers.
Contraindicated in G6PD deficiency.
and
and
42 What do untoward reactions to sulfonamides include?
Haemolytic anaemia
Discoloured teeth
Crystaluria
Kernicterus
and
and
and
and
43 Which of the following Chelators is preferred in the treatment of Wilson's disease?
Unithiol
D -Penicillamine
EDTA
Deferoxamine
44 Which of the following antiviral drugs is topically used for HSV keratitis?
Gancydovir
Acyclovir
Idoxuridine
Amantadine
45 Which of the following injectable local anesthetics is administered only in subarachnoid space?
Procaine
Amithocaine
Bupivacaine
Lignocaine
46 On which of the opioid receptors does methadone act predominantly?
Delta
Kappa
Mu
Sigma
47 Which of the following metals is primarily bound in skin, hair and nails?
Lead
Copper
Zinc
Arsenic
48 Which of the following classes of drugs are l.lsed in dry unproductive cough?
Mucolytics
Expectorants
Anti -tussives
Anti -histaminics
and
and
and
and
49 What is the major route of absorption for elemental Mercury
Respiratory tract
Gastrointestinal tract
Skin
Eyes
50 Haemolysis with primaquine due to G -PD deficiency is an example of
Genetic defect leading to variation in drug action
Disease induced modification in drug action
Cross tolerance reaction
Tachyphylaxis
51 What is true of penicillamine
It is a narrow spectrum antibiotic.
It is orally absorbed.
It chelates copper, mercury, zinc and lead.
Long term use may cause cutaneous lesions
and
and
and
and
52 Which of the following are the features of a cardioselective 13(beta) blocker?
Does not cause dyslipidaemia
Less liable to impair exercise capacity
Safer in diabetics (as compared to non -selective 13 blocker).
Suppresses essential tremor.
and
and
and
and
53 In a patient suffering from liver cirrhosis, the following effects on drug action may occur.
BioavailabiIity of drugs undergoing high first pass metabolism.
Protein binding of acidic drugs may decrease.
Dose of drugs getting metabolised by hepatic microsomal enzymes has to be reduced.
Dose of drugs excreted in an unchanged form has to be reduced.
and
and
and
and
54 Which of the following drugs is known to cause Raye's Syndrome?
Phenacetin
Sulindac
Dicofenac
Aspirin
55 What does Edetate Calcium Disodium effectively treat?
Lead poisoning
Mercury poisoning
Arsenic poisoning
Artherosc1erotic plaques
andid)
and
56 Which of the following insulin preparations of bovine origin is short acting?
Insulin -Zinc suspension amorphus (semi -lente)
Insulin -Zinc suspension (lente)
Insulin -.Zinc suspension crystalline (ultra-Iente)
Isophane
57 Match the given antifungal drugs with their mechanism of action:
Column A (drugs) Column B (Mechanism)
Amphotericin B Inhibits eryosterol synthesis
Fluconazole Alters permeability of cell membrane
Flucytosine Inhibits DNA and RNA synthesis
Terbinafine Accumulation of sterol squalene
58 Which substance is antagonized by Naloxone?
Propranolol
Labetalol
Opioid receptor
Salbutamol
59 What is not true of Aspirin?
It is a very safe drug.
It is a selective COX2 inhibitor.
It can induce platelet aggregation.
It can induce asthma.
and
and
and
and
60 What are the important features of amoxicillin
It is penicillinase resistant.
It is bactericidal for both gram positive and gram negative bacteria.
Incidence of diarrhoea is less.
Indicated in respiratory injections
and
and
and
and
61 What is the commonest cause of malaria in the world?
P. Vivex
P.Ovale
P. Falciparum
P. Malariae
62 Complete the sentence: Tyndal developed a method for control of microorganisms called as Tyndallization in which
Intermittent sterilization is done
Boiling is done
Autocleving is done
Pasteurization is done
63 The Epsilometer test is employed to
find severity of infection.
determine the efficacy of antibiotic heatment.
find the titre of the antibodies.
determine the minimum inhibitory concentration of an antibiotic.
64 Man is dead end for:
Typhoid
Diphtheria
Rabies
AIDS
65 Stormy clot reaction is typically seen in infection by
Borrelia
Treponema
Clostradium welchii
H. influenzae
66 Genetic mechanism of bacterial drug resistance includes:
Mutations occur at the rate 10-5 lo 10-9 cells per generation.
Recombination between two cells, each resistant to different drugs can produce a cell resistant to both.
A plasmid carrying gene introduced into cell population usually infect every other cell.
and
and
and
67 Development of the concept of aseptic technique was devised by
Louis Pasteur
Joseph Lister
Robert Koch
Paul Ehrlich
68 Scintillation counter is used for which tests:
ELISA
RIA
CIM
H1N1
only
only
both
only
69 One of the following is not an enzyme used in ELISA:
beta -galactosidase
glucose oxidase
alkaline phosphatase
coagulase
70 In microorganism growth is an important metabolic process involving the following steps. Arrange them in their chronological order.
Cell division
Morphogenesis
Differentiation
Expansion
Choose the correct option.
71 Which cell is involved in the speCific immune response?
Monocytes
Lymphocytes
Endocytes
Nuc1eocytes
72 Aggressins are nothing but:
Group of chemical compounds resembling hormones.
Substances that activate the host response system.
Group of diffusable cellular components produced by certain pathogen.
Substance that inactivates the host immunity.
73 What is the temperature -pressure combination for an autoclave?
100 degrees c and 4 psi
121 degrees c and 15 psi
131 degrees c and 9 psi
115 degrees c and 3 psi
74 The primary effect of ultra -violet radiations is on microbial:
carbohydrates
enzymes
nucleic acids
cell walls
75 Urinary tract infection is most often caused by
E. coli
Proteus
Klebsiella
Pseudomonas
76 The penicillin family of antibiotics is used primarily against:
viruses
fungi
gram negative bacteria
gram positive bacteria
77 Cocci arranged in packet of eight are
Staphylococci
Streptococci
Pneumococci
Gaffkyi
78 Streptococcus Pneumoniae may cause:
gonorrhea
otitis media
endocarditis
wound infection
79 Cephalosporins are produced by
Unicellular bacteria
Filamentous bacteria
Molds
Algae
80 A fever inducing substance is known as
exotoxin
endotoxin
pyrogens
enterotoxin
81 Temperature in Hot -air oven for sterilization may be
210°C for 1/2 hr
180°C for 1 hr
160°C for 1 1/2 hr
Only is true
Only is true
Only is true
and are true
82 In India, viral hepatatis is most commonly caused by
Hepatatis A
Hepatatis B
Non A Non B Hepatatis
Delta Hepatatis
83 Drug resistance can be transferred by
R -plasmid from one bacteria to another
the process of transduction.
both are true
only is true
both are false
only is true
84 Disinfection means
When an article is freed of all microorganisms
Destruction of all pathogenic microorganisms
Prevention of infection
Inhibiting growth of bacteria
85 Hydrophobia is caused by rabies virus, its incubation period seems to be related to
Vaccination
Distance between site of bite and CNS (Central Nervous System)
Types of vector
Infecting dose of virus
86 Widal test is carried out for the diagnosis of Typhoid, what is true of the widal reaction?
Antibodies to Ag appear first and persist.
Antibodies to Ag appear first and persist.
Antibodies to O'Ag appear simultaneously.
Antibodies to'H Ag persist.
87 Consider the following statements:
Gnotobiotic animals have only certain known strains of bacteria and other microorganisms.
Gnotobiotic animals do not have well developed immune systems, lower cardiac output and high susceptibility to infections.
Now state whether:
is true
is true
and are true
both are false
88 The BOD of effluent is affected by
The organic matter content.
The oxidizable inorganic matter content.
pH of the effluent.
Coloured substances.
89 Match the following:
List I List II
S. aureus UTI infection
E. coli Respiratory tract infection
C. diphtheriae Opportunistic infection
P. Vulgaris Wound infection
90 What is laboratory diagnosis of enteric fever based on
Blood culture
Urine culture
Widal test
Stool culture
and
and
and
and
91 Match the following proteins with their specific functions in DNA replication.
Helicases Processive unwinding of DNA
DNA primases Seals the single strand
DNA Ligases Relieves torsional strain
Topoisomerases Initiates synthesis of RNA primers
Answer options
92 Match the following: Unsuitable characteristics for sustained release Drug
Long t 1/2 Furosemide
Absorbed and excreted rapidly Digitoxin
No effective absorption in lower intestine Diazepam
Low therapeutic index Riboflavin
93 In the RNA molecule:
guanine content does not equal cytosine content.
guanine content equals cytosine content.
adenine content does not equal uracil content.
adenine content equals uracil content.
Answer options
and only
and only
and only
and only
94 Enzyme immobilization makes use of the following materialjs as matrix:
calcium algenate
kappa -carrageenan
furcellaran
none of the above
Options:
and
only
only
and
95 Consider the following:
Chlorhexidine and salts, phenol
Hexamethylene tetramine
Benzalkonium chloride
Phenyl mercuric acetate
Which of the above is/are used as broad spectrum preservatives in emulsion?
Only
Only
and
All of the above
96 Commercial levels of phenylalanine can be obtained from:
A. niger
B. subtilis
E. coli
C. albicans
Options:
and
and
only
only
97 The Michaelis -Neuton equation relates the velocity of a reaction catalysed by an enzyme with:
Concentration of product formed
Concentration of substrate required
Collision frequency
Energy of activation
98 When internal stresses in the film exceeds, the tensile strength of the film results in
Blistering
Cracking
Bloom
Bridging and Filling
Only
Only
and
99 Gibberellin, a secondary metabolite of microbes, is
an antibiotic
an anti-ulcer agent
a plant growth regulator
an immunosuppressant
Options:
and
only
only
only
100 Which of the following molecule/s is/are not steroidal in nature?
dafachromic acid
aramchol
sterchamol
brassinolide
Options:
only
and
only
and
101
Compounds and are
positional isomers
chain isomers
functional isomers
none of the above
102 Citric acid is the primary metabolite obtained from:
Saccharomyces cerevisiae
Aspergillus niger
Corynebacterium glutamicum
Xanthamonas species
103 Consider the following:
t 10% -ln 0.90/K1
t 10% 0.105/K1
Which of the above is/are used to compute shelf life?
Only
Only
Both and
Neither nor
104 The 7-methyl guanosine triphosphate caps at the end of m-RNA molecules in mammals are necessary for
processing of primary transcript to m -RNA.
translation of m -RNA.
protection of m -RNA.
synthesis of DNA.
Answer options
and only
and only
alone
and only
105
Compounds and are
positional isomers
chain isomers
functional isomers
geometric isomers
106 A characteristic of vaccines made from live attenuated organisms is
they usually require more than one dose to induce a full immune response.
they are prepared using recombinant DNA technology.
they trigger both antibody production and cell-mediated responses.
they trigger antibody production only.
107 The sugar in DNA and RNA, respectively are:
ribulose and deoxyribulose
deoxyribose and ribose
deoxyribofuranose and furanose
ribose and deoxyribose
108 Match the following:
Polyalkoxyethers Lauryl alcohol
Polyalkoxyesters Polyoxyethylene sorbitan acid esters
Ammonium phosphate Polyoxyethylene polyoxypropylene block polymer
Fatty alcohols Lecithin
109 FMC corporation has developed patented aqueous enteric coating called as
Aquateric
Aquateric and Eudragit
HPMCP 50
Aquateric, Eudragit and HP-555
110 A particular class of emulsifier is selected primarily on the basis of
Required shelf life
Route of administration
Type of emulsion
Emulsifier cost
Options:
only
and
and
none of the above
111 Isomers formed by the inter-conversion, based only on the rotations about single bonds are called as
conformational isomers
conformers
rotamers
stereomers
Options:
and
and
only
and
112 Excess glucose is stored in the body by the process of
glycogenolysis
glycogenesis
lipolysis
gluconeogenesis
113 Test required for treated soda lime glass i.e Type II is/are:
Light transmission
Water attack at 121 test
Multiple internal reflectance
Water vapour permeation
Which of the statements given above is/are correct?
Only
Both and
and
and
114 Match the following
Emulsifier HLB value
Sodium oleate 2.1
Sorbitan monolaurate 7.1
Sucrose dioleate 8.6
Sorbitan tristearate 18.0
115 The precursor for biosynthesis of steroids in the body is
acetyl -CoA
glycogen
amino acids
fatty acids
116 A chemostat is nothing but:
a nutrient -limited self-balancing culture system
a statistical software for chemical systems
a chemical used as a hemostat
none of the above
117 Metabolism of amino acids involves all of the following except:
transamination
deamination
beta oxidation
citric acid cycle
118 A period of adaptation of microbes is also referred to as
growth phase
lag phase
log phase
stationary phase
119 Agents that cut DNA at specific sequences in Recombinant DNA Technology are called:
Exonucleases
Phages
Plasmids
Restriction enzymes
120 Which of the following is/are example/s of enteric coated polymers?
Sodium carboxymethyl cellulose
Polyethylene glycols
Cellulose acetate phthalate
Acrylate polymers
Only
Only
Only
All of the above
121 Reverse phase liquid-liquid chromatography means
the stationary phase is polar compound and the mobile phase is a non-polar solvent
the direction of flow of the mobile phase is reversed
the stationary phase is a non-polar compound and the mobile phase is a polar solvent
pre-derivatisation is done to less polar compound
122 Which of the following statements give the advantages of HPTLC over TLC
Sample volumes are in the lower nanolitre range
Solvent migration is faster
Efficient for dilute samples after extraction
HPTLC layers are of finer particle size
Answer options
Only and are correct
and are incorrect
and are incorrect
is correct but and are incorrect
123 Scanning densitometer is a part of
high pressure liquid chromatograph
high pressure thin layer chromatograph
gas liquid
gas solid chromatograph
124 Which of the following is most affected by the temperature changes in flame photometry
absorption spectrometry
atomic spectrometry
emission spectrometry
molecular spectrometry
125 "Figures of merit" used to evaluate the performance characteristics of an analytical technique include
Linearity range
Coefficient of selectivity
Coefficient of variation
Systematic error
Answer options:
and only
and only
and only
and
126 Squalane, the stationary phase used in CLC, is chemically
a high molecular weight saturated hydrocarbon
a high molecular weight unsaturated hydrocarbon
a low molecular weight complex
a high molecular weight complex
127 If a drug is manufactured under a name which belongs to another drug then it is known as
Spurious
Misbranded
Adulterated
Genuine
128 A Mass Spectrometer is linked to a LC so that:
exact mass of the mixture can be determined by Mass Spectrometry before it is passed through LC.
liquid used as mobile phase in LC is first purified by Mass Spectrometer.
substances can be separated in LC and then passed through Mass Spectrometer.
substances can be separated by Mass Spectrometer and then passed through LC.
129 Processes occurring during atomization Atomic Absorption Spectrometry are in the order:
Desolvation
Ionization
Nebulization
Volatilization
Dissociation
Answer options
130 Anastomosis are typically performed on
blood vessels
gastro-intestinal tract
urinary tract
none of the above
Options:
only
and
and
only
131 The advantages of Fourier Transform IR over Dispersive IR include the following, except:
Sample is exposed to the entire IR beam at a time
Only radiation of a narrow frequency falls on the detector at a time
Use of laser provides high frequency accuracy
Emission of IR radiation by the sample is not detected
132 Which of the following detector/s used in"Gas chromatography are mass flow sensitive?
Thermal conductivity
Flame ionization
Photo ionization
Electron capture
133 Drug shall be deemed to be misbranded, if it is:
not labelled in prescribed manner
colored, coated or polished, damage is concealed
made to appear better or greater therapeutic value than it really is
Which of the statement/s given above is/are correct?
only
and only
and only
and
134 High risk of infection and scarring are mainly disadvantages of
Sutures
Staples
Stenstrips
Tissue-glues
135 Which of the following committees advises the DTAB and various governments?
D.C.C
D.E.C
C.C.U.M
P.C.I
only
only
and
only
136 Laryngoscope is used to examine
lungs
vocal cords
glottis
kidneys
137 As per the limit test for heavy metals I.P., method D involves the use of
ignition at 500 to 600
thioacetamide reagent
hydrogen sulphide
sodium sulphide
138 Duties of government analyst are
To analyse or test the samples of drugs and cosmetics
To investigate any complaint in writing made to him
Which of the above statement/s is true?
Only is true
Only is true
Both and are true
Neither nor is true
139 The efficiency of a column in chromatography is defined in terms of
shape of the peaks obtained
retention factor
variance per unit length
selectivity factor
140 The schedule in D and C act that deals with particulars to be shown in manufacturing and analytical records of drugs is
Options:
Schedule V
Schedule X
Schedule U
Schedule W
141 Consider the following with respect to UV spectroscopy:
sigma to sigma* transitions occur in compounds having no lone pair of electrons
n to sigma* transitions occur in saturated compounds with no lone pair of electrons
aliphatic alcohols are used when measurements are made in the 200 to 260 nm range
Saturated hydrocarbons are used when measurements are made in the 200 to 260 nm range
Answer options
Only and are correct
Only and are correct
Only is incorrect
Only and are correct
142 Schedule Y deals with:
manufacture of new drugs
standards for cosmetics
standards for ophthalmic preparations
requirements and guidelines for clinical trials
only
and
and
and
143 Arsine gas in the limit test for arsenic is produced by the reaction between:
H3AsO3 and HZSn03
H3AsO4 and HzSnO2
H3AsO3 andHz
H3AsO4 and H2
144 Which of the following statements is/are true?
Drug inspector has no financial interest in the import, manufacture or sale of drugs.
Drug inspector is a public servant.
Drug inspector should have qualifications as per section 20 of the Act.
Only
Only
and
All of the above
145 A drug sample taken by drug inspector for analysis is sent to
Drug Controller
State Drug Laboratory
Excise Commissioner
Government Analyst
and
only
only
and
146 Dithione, used in the limit test of lead, is chemically:
diphenylthiocarbazone
diphenylthioazone
dimethylthiocarbazone
dimethylthioazone
147 A jet separator in LC-MS, works on the principle of
Venturi action
Solubility of a separated fraction in an elastomer
Solubility of the mobile phase in an elastomer
Permeability of a separated fraction through an elastomer
148 Consider the following:
The Drug Controllor of India
The Director, Central Drug Laboratory
The President, Pharmacy Council of India
The Director General of Health Services
Which one of the above is the chairman of the Drugs Technical Advisory Board?
only
only
only
None of the above
149 Match the following
Schedule Factory Premises for
M manufacture of cosmetics
M II manufacture of drugs
M III manufacture of homeopathic drugs
M I manufacture of medical devices
150 Hemostat is used to
degrade heme
control bleeding during surgery
stop degradation of haemogloblin
none of the above
151 A recent report by the American Heart Association which was also reported in the media, discusses the vulnerability of people to heart disease in relation to their blood groups. Which of the below mentioned statements are true according to the report
People with blood group AB are least vulnerable.
People with type 0 blood group are least vulnerable.
The order of decreasing vulnerability is AB, O.
There is no relation found between blood grouping and heart disease.
Only is true
and are true
Only is true
None of the above
152 Permitted daily exposure for class II solvents is
0.1mg/ day
1mg/ day
10mg/ day
0.01mg/ day
153 Approval for the first generic AtoS (Pioglitazone hydrochloride) tablet to treat type 1 diabetes has been granted by FDA to which of the companies?
Mylon pharmaceuticals
Cadila pharmaceuticals
Pfizer pharmaceuticals
Orthobiotech Pvt. Ltd
and
and
only
only
154 Out of the publications mentioned below one or more are not considered to be a part of Indian Pharmaceutical guide:
Drug Today
Pharma Pulse
MIMS
CIMS
Options:
and
and
only
only
155 Which of the following sections of population are beneficiaries of the ICDS programme?
Women above 60 years
Children below 6 years
Pregnant and lactating women
Women in the age group 15-44 years
and
and
and
and
156 New drugs recommended by NDAC for marketing without clinical trial:
Cabazitaxel
Crizotinib
Degarelix
Clopidoprel
and
and
and
157 "Cannabis according to Narcotics and Psychotropic Substances Act, 1985 includes
ecgonine and all its derivatives from which ecgonine can be recovered.
ganja, that is, flowering or fruiting tops of the cannabis plant.
phenanthrene alkaloids, such as morphine and codeine.
charas, that is resin obtained from cannabis plant.
and
and only
and
and only
158 The Clinical Trials Registry India has been set up with which of the following objectives
Improve transparency and accountability of clinical trials.
Conformation of clinical trials to accepted ethical standards.
Reporting of all relevant results of registered clinical trials.
Advise regarding recruitment of subjects for clinical trials.
and only
and only
and
and only
159 The Central Drugs Authority has following divisions:
Regulatory and Enforcement
New Drugs and Clinical Trials
Issue of licences for retail sale of drugs
Imports of Drugs and Cosmetics
and
and
and
and only
160 The NPPA has issued clarification 2012, in the press that price of one of the following drugs has not been raised -which drug is it
Norfloxacin
Cefotaxime
Insulin
Vitamin C
161 The Systemic Antidote for Acetaminophen is
Atropine
Activated charcoal
N-acetyl cysteine
EDTA
162 Which of the two modules have been recently added in good pharmacovigilance practices?
Module III pharmacovigilance monitoring
Module X Additional monitoring
Module V Risk management system
Module II pharmacovigilance system master file
and
and
and
and
163 Consider the following statements:
Chronic toxicity may not be of importance in antidote use.
An antidote which is non-toxic may be used even if its efficacy is uncertain.
A toxic antidote may be used even if the diagnosis of the cause is uncertain.
An antidote may mobilize the toxic substance from tissue stores.
Which of the above statements are true?
and only
and only
and
and
164 Compulsory licence has been granted for Anti cancer drug by Indian Patent Office to
Khandelwal Lab
Natco Vs Bayer
Panacea biotech
Sandoz Vs GSk
165 The requirement and guidelines for contract research comes under which schedule?
Sch M
Sch y-1
Sch C
Sch X
166 Which of the following drugs may be used for prophylaxis of malaria?
Chloroquine
Doxycycline
Ciprofloxacin
Metronidazole
and only
and only
and only
and
167 Novel chemical entity GRC 17536, that has recently completed phase I trials in Netherlands is the research initiated by which of the following pharmaceutical companies
Sanofi pharma
Hikal Ltd.
Glenmark pharmaceuticals
Jubiliant pharma
Options:
and
and
and
Only
168 According to DPCO, 1995, "Scheduled formulation" includes:
Formulation containing bulk drug individually specified in first schedule.
Formulation containing bulk drug specified in first schedule in combination with another not specified in the schedule.
Any single drug formulation based on drug specified in first schedule sold under generic name.
Formulation containing drugs not specified in first schedule.
only
and
and
and only
169 Inaugural address at "Two day Polio Summit, 2012" organised by Government of India and Rotary International at Delhi was given by one of the following personalities.
Dr. Manmohan Singh Prime Minister of India
Mr. Kalyan Banerjee President of Rotary International
Mr. Amitabh Bacchan
Ghulam Nabi Azad, Union Health Minister
170 Recently USFDA has approved a new drug for diabetic Macular edema named:
Ranibizumab inj
Thiabendazol
LAMA/LABA
Prasugrel
171 ISO 14000 is primarily concerned with one or more than one of events mentioned below:
Chemical safety
Automotive belts
Quality management
Environmental safety
172 According to a report published in the 'Lancet' and reported in news print media, what is/are Africa's new health problem/s
War and poverty
Famine and disease
Obesity
HIV-AIDS
and both
and
only
only
173 India's First Indigenously developed new medicine by Ranbaxy is
Combination of Arterolane maleate Piperaquine P04
Chloroquine Sulfadoxine Pyrimethamine
Amodiquine Sulfadoxine Pyrimethamine
Artemethur
174 Recently, which of the following anti-epileptic drugs has been reported to reverse memory loss due to Alzheimer's disease in mouse model
Levetiracetam
Phenobarbitone
Ethosuximide
Carbamazepine
175 Which Antidiabetic drug has been recently bannedin India for human use 7
Rosiglitazone
Chlorhexidine
Nateglinide
Acetohexamine
176 What will be the next term in the given sequence Find it from given alternatives. ADE, CFG, EHI, GJK,
IML
ILM
MIL
LMI
177 If means' means' and means' Then what will, be the value of 18 Q 12 P 4 R 5 T 6
53
56
59
65
178 As is related to and is related to will be related to
NP
OR
OQ
PR
179 First word bears some definite relationship with the second. From the given alternatives, select the suitable word for'serial number four, which bears the same relation with the third word, that the second has with the first.
Book: Author: Statue:
Painter
Binder
Sculptor
Calligraphist
180 In a code language means 'Red Colour Chalk', means 'Green Colour Flower' and means 'White Colour Chalk'. What is the code for white 7
4
5
6
181 There are three numbers outside and one number inside of two triangles. They are according to some formula. Find the formula and the number at in the third triangle, from given alternatives.
12
9
7
182 Four numbers in each square are according to some formula. Find it and from that find the value of from given alternatives.
5
6
8
7
183 In a code language P R O B L E M is written as M P E R L O B. How N U M B E R S will be written in that code language?
S N U R E M B
S N R U B M E
S N R U E M B
S N R U M E B
184 Which of the figures in given alternatives belongs to the space marked
185 What will be the next term in the given series? B B C B C D B C D E B C D E F B C D E F G B C D E F
B
G
H
D
186 Which letter should go in the blank space
D
E
F
G
187 In a certain code READ is written as 6 and PAID is written as 46. How RIPE will be written in that code?
4 5
6 5
4 5
4 6
188 Which of the following figures will represent the relationship between ball, football and sphere?
189 There is a definite relationship between figures A and B. Establish the similar relationship between figures C and by choosing a suitable figure from given alternatives.
190 Some boys are standing in a row, facing towards North. Ajay is 12th from left. If he moves four places to right, he appears at the place, 18th from right'. What is the total number of boys in the row?
32
33
34
Information is not sufficient
191 A wooden block is shown in the figure. How many different surfaces does the block have?
8
9
10
7
192 Find the missing terms in the given series: 10, 17, 26,
50, 65
45, 65
50, 60
50, 75
193 The numbers in three figures follow some rule, which is not followed by the numbers in one figure. Find the figure, which is different from others.
194 Out of the four groups of letters, three are similar in some way. Find the odd one.
H K
B D
F I
M P
195 Out of the four given figures, three are similar in some way. Choose the figure which is different from the rest.
196 Select the numbers from given alternatives, which will complete the given sequence. 95, 81, 74
102, 87
102, 88
103, 88
101, 89
197 A figure series is given with a blank space shown by Select the suitable figure from given alternatives, which will continue the same series.
198 The given figun;s definite sequence. Fill in the blank space with the suitable figure from given alternatives which should come next.
199 In column I groups of letters and the codes for them are given, not necessarily in the sequence. Each number stands for a letter. What is the code for
Column I Column II
(Groups of Letters) (Codes)
A N P 5 2 4
N M C 1 2 3
P M A 3 4 1
4
3
2
200 The relation between the two terms to the left of and that between the two terms to the right of is same. Find the term at from given alternatives.
E V
U E
V E
E U
Affinity tags are long peptide sequences.
Affinity tags have 4 consecutive tyrosine residues.
Affinity tags have 6 consecutive histidine residues.
Affinity tags have 8 different amino acid residues.
2 Which anticoagulants are permitted to be used for storing whole Human Blood as per IP
Anticoagulant Citrate Dextrose solution
Anticoagulant Citrate Phosphate Dextrose solution (ACPD)
Low Molecular Weight Heparins (LMWHs)
Sodium Warfarin
and
and
and
and
3 Place the steps involved in hemostasis in the correct order of their occurrence:
Conversion of fibrinogen to fibrin
Conversion of prothrombin to thrombin
Activation of intrinsic or extrinsic pathway
Formation of prothrombinase.
and
and
and
and
4 What is the correct combination of temperature and duration of storage respectively for preservation of Cryoprecipitate?
-20°C for 6 months
-20°C for 9 months
-30°C for 9 months
-30°C for 12 months
5 What is the maximum volume of blood advised to be donated within consecutive period of 12 months
1.0 L
1.2 L
1.5 L
1.8 L
6 Which chemical is released by platelets when they adhere to the damaged wall
Histamine
5 -Hydroxytryptamine
Acetylcholine
Adrenalin
7 How many types of antigens have been detected on the surface of Red Blood Cells
Five
Ten
Fifty
More than one hundred
8 In which disease, Type -IV Hypersensitivity reaction causes chronic intestinal inflammation and obstruction?
Contact dermatitis
Rheumatoid arthritis
Crohn disease
Multiple sclerosis
9 What is not true of the Haemolytic disease of newborns?
It can affect malnourished newborns.
Causes jaundice.
Occurs because of incompatible blood transfusion in newborns.
Can be prevented by injecting the mother with anti agglutinins just after delivery.
and
and
and
and
10 When is HBIG administered to an infant born to HBs Ag positive mother?
Within 7 days after birth
Within 1 day after birth
Within 8 hours after birth
Within 12 hours after birth
11 What is not true of the composition of blood?
Plasma forms 91.5% of blood.
WBCs are largely responsible for the viscosity of blood.
Albumins form the major group of plasma proteins.
Macrophages are a type of circulating RBCs.
and
and
and
and
12 Which hemopoietic growth factor regulates conversion of myloid stem cells to myloblasts
Colony Forming Unit -Erythrocyte
Colony Forming Unit -Leukocyte
Colony Forming Unit -Granulocyte Macrophage
Colony Forming Unit -Erythropoietin
13 What is not true of the cord stem cells?
They are easily collected.
They are more in stem cells than in red bone marrow.
The match between donar and recipient has to be exact in a transplant.
Less likely to transmit infections.
and
14 What is not true of the intrinsic pathway of coagulation?
It is fast and simple.
Its activators are in direct contact with blood.
Outside tissue damage is not needed.
Contact with collagen fibres activates factor XII.
15 The following is true about anaphylactic reactions:
Occurs within a few minutes after exposure to allergen in a previously sensitised person.
IgE antibodies and mast cells play an important role
Rheumatoid Arthritis is an example.
Penicillin can cause it in a few people.
and
and
and
and
16 Which organism is known to cause Lymphogranuloma Venereum in both the sexes?
Neisseria gonorrhoeae
Trichomonas vaginalis
Treponema pallidium
Chlamydia trachomatis
17 What is true of the Genital Herpes?
It is not curable
It is recurrent
Caused by HSV
Chancres are produced in advanced stages.
and
and
and
and
18 How much minimum percent Haemoglobin content should whole Human Blood contain?
11.1
10.2
9.7
8.5
19 Which type of antibody causes anaphylaxis leading to vascular dilation and edema leading to inflammation
IgE
IgA
IgD
IgM
20 What is the chemical nature of antigens present on the surface of RBCs
Phospholipid
Glycolipid
Lipopoly saccharide
Glycoprotein
21 Which organ or its part is affected by ureaplasma urealyticum
Ureter
Urethra
Nephron
Glomerulus
22 Match the blood group with the colour scheme of the labels:
Column A Column B
(Blood group) (Label colour)
O Yellow
A White
B Blue
AB Pink
23 HIV mainly damages follOWing types of cells.
Halper T cells
Natural Killer Cells
Red blood cells
Eosinophils
24 Which of the following is/are activated by thromboplastin?
Fibrinolytic system
Extrinsic coagulation pathway
Platelet aggregation
Graft Vs host reaction
only
and
and
and
25 A hematocrit of 40 indicates the following:
Blood forms 40% of body fluids.
RBCs form 40% of the total volume of blood.
RBCs, WBCs and platelets together form 40% of the total volume of blood.
Haemoglobin is 40% lower than normal range.
26 Fill in the blank. Tissue type plasminogen activator that cleaves plasminogen to form plasmin is a enzyme.
Nuclease
Amylase
Protease
Lipase
27 What is the quantum of formed elements in whole blood?
40%
45%
55%
60%
28 Which are the two most important constituents of Fibrin sealant kit
Fibrinogen and thrombin
Prothrombin and thrombin
Fibrin and Fibrinogen
Vitamin K and thromboplastin
29 When did the Government of India publish National Blood Policy?
1950
1991
2002
2010
30 Which is the most common viral antigen found on the surface of HIV
P 24
P 12
P 3128
P 8080
31 What are the anti -viral drugs recommended for treatment of H1N1 viral infections?
Oseltamivir
Zanamivir
Acyclovir
Lamivudin
and
and
and
and
32 What drugs are used to terminate early pregnancy?
Finasteride
Tamoxifen
Clomiphene
Mifepristone
and
33 What is not true of oxytocin?
It acts through a protein coupled receptors.
Number of oxytocin receptors increc1se in late pregnancy.
It is used in uterine inertia.
Estrogens desensitize uterus to oxytocin.
and
and
34 What is the threshold limit value for chloroform at a workplace?
2 ppm
3 ppm
5 ppm
10 ppm
35 What is the main site of action for steroid hormones?
Cytoplasm
Plasma membrane
Nucleus
Mitochondria
36 In which of the following organs Fluoride and Lead get concentrated?
Body fat
Intravascular space
Extracellular space
Bones
37 Which of the following antiepileptic drugs acts as a GABA transaminse inhibitor?
Sodium valproate
Vigabatrin
Tiagabine
Gabapentine
38 Which of the following drugs is given during hypertensive emergencies as a IV infusion?
Nifedipine
Nitroglycerine
Sodium Nitroprusside
Propranolol
39 What is not true of the mechanism of action of local anaesthetics?
They block conduction of Na ions.
A resting nerve is very sensitive to its action.
Small unmyelinated C fibers are blocked before the larger fibers.
The drug enters the cell in charged form.
and
40 What is the duration of each cycle of non -rapid eye movement (NREM) sleep?
90 min
10 min
60 min
30 min
41 What is not true of primaquine?
It is not useful in treatment of symptomatic malaria.
It is used to eradicate the hypnozoites of P.vivax and P. ovale.
Used for prophylaxis in healthy travellers.
Contraindicated in G6PD deficiency.
and
and
42 What do untoward reactions to sulfonamides include?
Haemolytic anaemia
Discoloured teeth
Crystaluria
Kernicterus
and
and
and
and
43 Which of the following Chelators is preferred in the treatment of Wilson's disease?
Unithiol
D -Penicillamine
EDTA
Deferoxamine
44 Which of the following antiviral drugs is topically used for HSV keratitis?
Gancydovir
Acyclovir
Idoxuridine
Amantadine
45 Which of the following injectable local anesthetics is administered only in subarachnoid space?
Procaine
Amithocaine
Bupivacaine
Lignocaine
46 On which of the opioid receptors does methadone act predominantly?
Delta
Kappa
Mu
Sigma
47 Which of the following metals is primarily bound in skin, hair and nails?
Lead
Copper
Zinc
Arsenic
48 Which of the following classes of drugs are l.lsed in dry unproductive cough?
Mucolytics
Expectorants
Anti -tussives
Anti -histaminics
and
and
and
and
49 What is the major route of absorption for elemental Mercury
Respiratory tract
Gastrointestinal tract
Skin
Eyes
50 Haemolysis with primaquine due to G -PD deficiency is an example of
Genetic defect leading to variation in drug action
Disease induced modification in drug action
Cross tolerance reaction
Tachyphylaxis
51 What is true of penicillamine
It is a narrow spectrum antibiotic.
It is orally absorbed.
It chelates copper, mercury, zinc and lead.
Long term use may cause cutaneous lesions
and
and
and
and
52 Which of the following are the features of a cardioselective 13(beta) blocker?
Does not cause dyslipidaemia
Less liable to impair exercise capacity
Safer in diabetics (as compared to non -selective 13 blocker).
Suppresses essential tremor.
and
and
and
and
53 In a patient suffering from liver cirrhosis, the following effects on drug action may occur.
BioavailabiIity of drugs undergoing high first pass metabolism.
Protein binding of acidic drugs may decrease.
Dose of drugs getting metabolised by hepatic microsomal enzymes has to be reduced.
Dose of drugs excreted in an unchanged form has to be reduced.
and
and
and
and
54 Which of the following drugs is known to cause Raye's Syndrome?
Phenacetin
Sulindac
Dicofenac
Aspirin
55 What does Edetate Calcium Disodium effectively treat?
Lead poisoning
Mercury poisoning
Arsenic poisoning
Artherosc1erotic plaques
andid)
and
56 Which of the following insulin preparations of bovine origin is short acting?
Insulin -Zinc suspension amorphus (semi -lente)
Insulin -Zinc suspension (lente)
Insulin -.Zinc suspension crystalline (ultra-Iente)
Isophane
57 Match the given antifungal drugs with their mechanism of action:
Column A (drugs) Column B (Mechanism)
Amphotericin B Inhibits eryosterol synthesis
Fluconazole Alters permeability of cell membrane
Flucytosine Inhibits DNA and RNA synthesis
Terbinafine Accumulation of sterol squalene
58 Which substance is antagonized by Naloxone?
Propranolol
Labetalol
Opioid receptor
Salbutamol
59 What is not true of Aspirin?
It is a very safe drug.
It is a selective COX2 inhibitor.
It can induce platelet aggregation.
It can induce asthma.
and
and
and
and
60 What are the important features of amoxicillin
It is penicillinase resistant.
It is bactericidal for both gram positive and gram negative bacteria.
Incidence of diarrhoea is less.
Indicated in respiratory injections
and
and
and
and
61 What is the commonest cause of malaria in the world?
P. Vivex
P.Ovale
P. Falciparum
P. Malariae
62 Complete the sentence: Tyndal developed a method for control of microorganisms called as Tyndallization in which
Intermittent sterilization is done
Boiling is done
Autocleving is done
Pasteurization is done
63 The Epsilometer test is employed to
find severity of infection.
determine the efficacy of antibiotic heatment.
find the titre of the antibodies.
determine the minimum inhibitory concentration of an antibiotic.
64 Man is dead end for:
Typhoid
Diphtheria
Rabies
AIDS
65 Stormy clot reaction is typically seen in infection by
Borrelia
Treponema
Clostradium welchii
H. influenzae
66 Genetic mechanism of bacterial drug resistance includes:
Mutations occur at the rate 10-5 lo 10-9 cells per generation.
Recombination between two cells, each resistant to different drugs can produce a cell resistant to both.
A plasmid carrying gene introduced into cell population usually infect every other cell.
and
and
and
67 Development of the concept of aseptic technique was devised by
Louis Pasteur
Joseph Lister
Robert Koch
Paul Ehrlich
68 Scintillation counter is used for which tests:
ELISA
RIA
CIM
H1N1
only
only
both
only
69 One of the following is not an enzyme used in ELISA:
beta -galactosidase
glucose oxidase
alkaline phosphatase
coagulase
70 In microorganism growth is an important metabolic process involving the following steps. Arrange them in their chronological order.
Cell division
Morphogenesis
Differentiation
Expansion
Choose the correct option.
71 Which cell is involved in the speCific immune response?
Monocytes
Lymphocytes
Endocytes
Nuc1eocytes
72 Aggressins are nothing but:
Group of chemical compounds resembling hormones.
Substances that activate the host response system.
Group of diffusable cellular components produced by certain pathogen.
Substance that inactivates the host immunity.
73 What is the temperature -pressure combination for an autoclave?
100 degrees c and 4 psi
121 degrees c and 15 psi
131 degrees c and 9 psi
115 degrees c and 3 psi
74 The primary effect of ultra -violet radiations is on microbial:
carbohydrates
enzymes
nucleic acids
cell walls
75 Urinary tract infection is most often caused by
E. coli
Proteus
Klebsiella
Pseudomonas
76 The penicillin family of antibiotics is used primarily against:
viruses
fungi
gram negative bacteria
gram positive bacteria
77 Cocci arranged in packet of eight are
Staphylococci
Streptococci
Pneumococci
Gaffkyi
78 Streptococcus Pneumoniae may cause:
gonorrhea
otitis media
endocarditis
wound infection
79 Cephalosporins are produced by
Unicellular bacteria
Filamentous bacteria
Molds
Algae
80 A fever inducing substance is known as
exotoxin
endotoxin
pyrogens
enterotoxin
81 Temperature in Hot -air oven for sterilization may be
210°C for 1/2 hr
180°C for 1 hr
160°C for 1 1/2 hr
Only is true
Only is true
Only is true
and are true
82 In India, viral hepatatis is most commonly caused by
Hepatatis A
Hepatatis B
Non A Non B Hepatatis
Delta Hepatatis
83 Drug resistance can be transferred by
R -plasmid from one bacteria to another
the process of transduction.
both are true
only is true
both are false
only is true
84 Disinfection means
When an article is freed of all microorganisms
Destruction of all pathogenic microorganisms
Prevention of infection
Inhibiting growth of bacteria
85 Hydrophobia is caused by rabies virus, its incubation period seems to be related to
Vaccination
Distance between site of bite and CNS (Central Nervous System)
Types of vector
Infecting dose of virus
86 Widal test is carried out for the diagnosis of Typhoid, what is true of the widal reaction?
Antibodies to Ag appear first and persist.
Antibodies to Ag appear first and persist.
Antibodies to O'Ag appear simultaneously.
Antibodies to'H Ag persist.
87 Consider the following statements:
Gnotobiotic animals have only certain known strains of bacteria and other microorganisms.
Gnotobiotic animals do not have well developed immune systems, lower cardiac output and high susceptibility to infections.
Now state whether:
is true
is true
and are true
both are false
88 The BOD of effluent is affected by
The organic matter content.
The oxidizable inorganic matter content.
pH of the effluent.
Coloured substances.
89 Match the following:
List I List II
S. aureus UTI infection
E. coli Respiratory tract infection
C. diphtheriae Opportunistic infection
P. Vulgaris Wound infection
90 What is laboratory diagnosis of enteric fever based on
Blood culture
Urine culture
Widal test
Stool culture
and
and
and
and
91 Match the following proteins with their specific functions in DNA replication.
Helicases Processive unwinding of DNA
DNA primases Seals the single strand
DNA Ligases Relieves torsional strain
Topoisomerases Initiates synthesis of RNA primers
Answer options
92 Match the following: Unsuitable characteristics for sustained release Drug
Long t 1/2 Furosemide
Absorbed and excreted rapidly Digitoxin
No effective absorption in lower intestine Diazepam
Low therapeutic index Riboflavin
93 In the RNA molecule:
guanine content does not equal cytosine content.
guanine content equals cytosine content.
adenine content does not equal uracil content.
adenine content equals uracil content.
Answer options
and only
and only
and only
and only
94 Enzyme immobilization makes use of the following materialjs as matrix:
calcium algenate
kappa -carrageenan
furcellaran
none of the above
Options:
and
only
only
and
95 Consider the following:
Chlorhexidine and salts, phenol
Hexamethylene tetramine
Benzalkonium chloride
Phenyl mercuric acetate
Which of the above is/are used as broad spectrum preservatives in emulsion?
Only
Only
and
All of the above
96 Commercial levels of phenylalanine can be obtained from:
A. niger
B. subtilis
E. coli
C. albicans
Options:
and
and
only
only
97 The Michaelis -Neuton equation relates the velocity of a reaction catalysed by an enzyme with:
Concentration of product formed
Concentration of substrate required
Collision frequency
Energy of activation
98 When internal stresses in the film exceeds, the tensile strength of the film results in
Blistering
Cracking
Bloom
Bridging and Filling
Only
Only
and
99 Gibberellin, a secondary metabolite of microbes, is
an antibiotic
an anti-ulcer agent
a plant growth regulator
an immunosuppressant
Options:
and
only
only
only
100 Which of the following molecule/s is/are not steroidal in nature?
dafachromic acid
aramchol
sterchamol
brassinolide
Options:
only
and
only
and
101
Compounds and are
positional isomers
chain isomers
functional isomers
none of the above
102 Citric acid is the primary metabolite obtained from:
Saccharomyces cerevisiae
Aspergillus niger
Corynebacterium glutamicum
Xanthamonas species
103 Consider the following:
t 10% -ln 0.90/K1
t 10% 0.105/K1
Which of the above is/are used to compute shelf life?
Only
Only
Both and
Neither nor
104 The 7-methyl guanosine triphosphate caps at the end of m-RNA molecules in mammals are necessary for
processing of primary transcript to m -RNA.
translation of m -RNA.
protection of m -RNA.
synthesis of DNA.
Answer options
and only
and only
alone
and only
105
Compounds and are
positional isomers
chain isomers
functional isomers
geometric isomers
106 A characteristic of vaccines made from live attenuated organisms is
they usually require more than one dose to induce a full immune response.
they are prepared using recombinant DNA technology.
they trigger both antibody production and cell-mediated responses.
they trigger antibody production only.
107 The sugar in DNA and RNA, respectively are:
ribulose and deoxyribulose
deoxyribose and ribose
deoxyribofuranose and furanose
ribose and deoxyribose
108 Match the following:
Polyalkoxyethers Lauryl alcohol
Polyalkoxyesters Polyoxyethylene sorbitan acid esters
Ammonium phosphate Polyoxyethylene polyoxypropylene block polymer
Fatty alcohols Lecithin
109 FMC corporation has developed patented aqueous enteric coating called as
Aquateric
Aquateric and Eudragit
HPMCP 50
Aquateric, Eudragit and HP-555
110 A particular class of emulsifier is selected primarily on the basis of
Required shelf life
Route of administration
Type of emulsion
Emulsifier cost
Options:
only
and
and
none of the above
111 Isomers formed by the inter-conversion, based only on the rotations about single bonds are called as
conformational isomers
conformers
rotamers
stereomers
Options:
and
and
only
and
112 Excess glucose is stored in the body by the process of
glycogenolysis
glycogenesis
lipolysis
gluconeogenesis
113 Test required for treated soda lime glass i.e Type II is/are:
Light transmission
Water attack at 121 test
Multiple internal reflectance
Water vapour permeation
Which of the statements given above is/are correct?
Only
Both and
and
and
114 Match the following
Emulsifier HLB value
Sodium oleate 2.1
Sorbitan monolaurate 7.1
Sucrose dioleate 8.6
Sorbitan tristearate 18.0
115 The precursor for biosynthesis of steroids in the body is
acetyl -CoA
glycogen
amino acids
fatty acids
116 A chemostat is nothing but:
a nutrient -limited self-balancing culture system
a statistical software for chemical systems
a chemical used as a hemostat
none of the above
117 Metabolism of amino acids involves all of the following except:
transamination
deamination
beta oxidation
citric acid cycle
118 A period of adaptation of microbes is also referred to as
growth phase
lag phase
log phase
stationary phase
119 Agents that cut DNA at specific sequences in Recombinant DNA Technology are called:
Exonucleases
Phages
Plasmids
Restriction enzymes
120 Which of the following is/are example/s of enteric coated polymers?
Sodium carboxymethyl cellulose
Polyethylene glycols
Cellulose acetate phthalate
Acrylate polymers
Only
Only
Only
All of the above
121 Reverse phase liquid-liquid chromatography means
the stationary phase is polar compound and the mobile phase is a non-polar solvent
the direction of flow of the mobile phase is reversed
the stationary phase is a non-polar compound and the mobile phase is a polar solvent
pre-derivatisation is done to less polar compound
122 Which of the following statements give the advantages of HPTLC over TLC
Sample volumes are in the lower nanolitre range
Solvent migration is faster
Efficient for dilute samples after extraction
HPTLC layers are of finer particle size
Answer options
Only and are correct
and are incorrect
and are incorrect
is correct but and are incorrect
123 Scanning densitometer is a part of
high pressure liquid chromatograph
high pressure thin layer chromatograph
gas liquid
gas solid chromatograph
124 Which of the following is most affected by the temperature changes in flame photometry
absorption spectrometry
atomic spectrometry
emission spectrometry
molecular spectrometry
125 "Figures of merit" used to evaluate the performance characteristics of an analytical technique include
Linearity range
Coefficient of selectivity
Coefficient of variation
Systematic error
Answer options:
and only
and only
and only
and
126 Squalane, the stationary phase used in CLC, is chemically
a high molecular weight saturated hydrocarbon
a high molecular weight unsaturated hydrocarbon
a low molecular weight complex
a high molecular weight complex
127 If a drug is manufactured under a name which belongs to another drug then it is known as
Spurious
Misbranded
Adulterated
Genuine
128 A Mass Spectrometer is linked to a LC so that:
exact mass of the mixture can be determined by Mass Spectrometry before it is passed through LC.
liquid used as mobile phase in LC is first purified by Mass Spectrometer.
substances can be separated in LC and then passed through Mass Spectrometer.
substances can be separated by Mass Spectrometer and then passed through LC.
129 Processes occurring during atomization Atomic Absorption Spectrometry are in the order:
Desolvation
Ionization
Nebulization
Volatilization
Dissociation
Answer options
130 Anastomosis are typically performed on
blood vessels
gastro-intestinal tract
urinary tract
none of the above
Options:
only
and
and
only
131 The advantages of Fourier Transform IR over Dispersive IR include the following, except:
Sample is exposed to the entire IR beam at a time
Only radiation of a narrow frequency falls on the detector at a time
Use of laser provides high frequency accuracy
Emission of IR radiation by the sample is not detected
132 Which of the following detector/s used in"Gas chromatography are mass flow sensitive?
Thermal conductivity
Flame ionization
Photo ionization
Electron capture
133 Drug shall be deemed to be misbranded, if it is:
not labelled in prescribed manner
colored, coated or polished, damage is concealed
made to appear better or greater therapeutic value than it really is
Which of the statement/s given above is/are correct?
only
and only
and only
and
134 High risk of infection and scarring are mainly disadvantages of
Sutures
Staples
Stenstrips
Tissue-glues
135 Which of the following committees advises the DTAB and various governments?
D.C.C
D.E.C
C.C.U.M
P.C.I
only
only
and
only
136 Laryngoscope is used to examine
lungs
vocal cords
glottis
kidneys
137 As per the limit test for heavy metals I.P., method D involves the use of
ignition at 500 to 600
thioacetamide reagent
hydrogen sulphide
sodium sulphide
138 Duties of government analyst are
To analyse or test the samples of drugs and cosmetics
To investigate any complaint in writing made to him
Which of the above statement/s is true?
Only is true
Only is true
Both and are true
Neither nor is true
139 The efficiency of a column in chromatography is defined in terms of
shape of the peaks obtained
retention factor
variance per unit length
selectivity factor
140 The schedule in D and C act that deals with particulars to be shown in manufacturing and analytical records of drugs is
Options:
Schedule V
Schedule X
Schedule U
Schedule W
141 Consider the following with respect to UV spectroscopy:
sigma to sigma* transitions occur in compounds having no lone pair of electrons
n to sigma* transitions occur in saturated compounds with no lone pair of electrons
aliphatic alcohols are used when measurements are made in the 200 to 260 nm range
Saturated hydrocarbons are used when measurements are made in the 200 to 260 nm range
Answer options
Only and are correct
Only and are correct
Only is incorrect
Only and are correct
142 Schedule Y deals with:
manufacture of new drugs
standards for cosmetics
standards for ophthalmic preparations
requirements and guidelines for clinical trials
only
and
and
and
143 Arsine gas in the limit test for arsenic is produced by the reaction between:
H3AsO3 and HZSn03
H3AsO4 and HzSnO2
H3AsO3 andHz
H3AsO4 and H2
144 Which of the following statements is/are true?
Drug inspector has no financial interest in the import, manufacture or sale of drugs.
Drug inspector is a public servant.
Drug inspector should have qualifications as per section 20 of the Act.
Only
Only
and
All of the above
145 A drug sample taken by drug inspector for analysis is sent to
Drug Controller
State Drug Laboratory
Excise Commissioner
Government Analyst
and
only
only
and
146 Dithione, used in the limit test of lead, is chemically:
diphenylthiocarbazone
diphenylthioazone
dimethylthiocarbazone
dimethylthioazone
147 A jet separator in LC-MS, works on the principle of
Venturi action
Solubility of a separated fraction in an elastomer
Solubility of the mobile phase in an elastomer
Permeability of a separated fraction through an elastomer
148 Consider the following:
The Drug Controllor of India
The Director, Central Drug Laboratory
The President, Pharmacy Council of India
The Director General of Health Services
Which one of the above is the chairman of the Drugs Technical Advisory Board?
only
only
only
None of the above
149 Match the following
Schedule Factory Premises for
M manufacture of cosmetics
M II manufacture of drugs
M III manufacture of homeopathic drugs
M I manufacture of medical devices
150 Hemostat is used to
degrade heme
control bleeding during surgery
stop degradation of haemogloblin
none of the above
151 A recent report by the American Heart Association which was also reported in the media, discusses the vulnerability of people to heart disease in relation to their blood groups. Which of the below mentioned statements are true according to the report
People with blood group AB are least vulnerable.
People with type 0 blood group are least vulnerable.
The order of decreasing vulnerability is AB, O.
There is no relation found between blood grouping and heart disease.
Only is true
and are true
Only is true
None of the above
152 Permitted daily exposure for class II solvents is
0.1mg/ day
1mg/ day
10mg/ day
0.01mg/ day
153 Approval for the first generic AtoS (Pioglitazone hydrochloride) tablet to treat type 1 diabetes has been granted by FDA to which of the companies?
Mylon pharmaceuticals
Cadila pharmaceuticals
Pfizer pharmaceuticals
Orthobiotech Pvt. Ltd
and
and
only
only
154 Out of the publications mentioned below one or more are not considered to be a part of Indian Pharmaceutical guide:
Drug Today
Pharma Pulse
MIMS
CIMS
Options:
and
and
only
only
155 Which of the following sections of population are beneficiaries of the ICDS programme?
Women above 60 years
Children below 6 years
Pregnant and lactating women
Women in the age group 15-44 years
and
and
and
and
156 New drugs recommended by NDAC for marketing without clinical trial:
Cabazitaxel
Crizotinib
Degarelix
Clopidoprel
and
and
and
157 "Cannabis according to Narcotics and Psychotropic Substances Act, 1985 includes
ecgonine and all its derivatives from which ecgonine can be recovered.
ganja, that is, flowering or fruiting tops of the cannabis plant.
phenanthrene alkaloids, such as morphine and codeine.
charas, that is resin obtained from cannabis plant.
and
and only
and
and only
158 The Clinical Trials Registry India has been set up with which of the following objectives
Improve transparency and accountability of clinical trials.
Conformation of clinical trials to accepted ethical standards.
Reporting of all relevant results of registered clinical trials.
Advise regarding recruitment of subjects for clinical trials.
and only
and only
and
and only
159 The Central Drugs Authority has following divisions:
Regulatory and Enforcement
New Drugs and Clinical Trials
Issue of licences for retail sale of drugs
Imports of Drugs and Cosmetics
and
and
and
and only
160 The NPPA has issued clarification 2012, in the press that price of one of the following drugs has not been raised -which drug is it
Norfloxacin
Cefotaxime
Insulin
Vitamin C
161 The Systemic Antidote for Acetaminophen is
Atropine
Activated charcoal
N-acetyl cysteine
EDTA
162 Which of the two modules have been recently added in good pharmacovigilance practices?
Module III pharmacovigilance monitoring
Module X Additional monitoring
Module V Risk management system
Module II pharmacovigilance system master file
and
and
and
and
163 Consider the following statements:
Chronic toxicity may not be of importance in antidote use.
An antidote which is non-toxic may be used even if its efficacy is uncertain.
A toxic antidote may be used even if the diagnosis of the cause is uncertain.
An antidote may mobilize the toxic substance from tissue stores.
Which of the above statements are true?
and only
and only
and
and
164 Compulsory licence has been granted for Anti cancer drug by Indian Patent Office to
Khandelwal Lab
Natco Vs Bayer
Panacea biotech
Sandoz Vs GSk
165 The requirement and guidelines for contract research comes under which schedule?
Sch M
Sch y-1
Sch C
Sch X
166 Which of the following drugs may be used for prophylaxis of malaria?
Chloroquine
Doxycycline
Ciprofloxacin
Metronidazole
and only
and only
and only
and
167 Novel chemical entity GRC 17536, that has recently completed phase I trials in Netherlands is the research initiated by which of the following pharmaceutical companies
Sanofi pharma
Hikal Ltd.
Glenmark pharmaceuticals
Jubiliant pharma
Options:
and
and
and
Only
168 According to DPCO, 1995, "Scheduled formulation" includes:
Formulation containing bulk drug individually specified in first schedule.
Formulation containing bulk drug specified in first schedule in combination with another not specified in the schedule.
Any single drug formulation based on drug specified in first schedule sold under generic name.
Formulation containing drugs not specified in first schedule.
only
and
and
and only
169 Inaugural address at "Two day Polio Summit, 2012" organised by Government of India and Rotary International at Delhi was given by one of the following personalities.
Dr. Manmohan Singh Prime Minister of India
Mr. Kalyan Banerjee President of Rotary International
Mr. Amitabh Bacchan
Ghulam Nabi Azad, Union Health Minister
170 Recently USFDA has approved a new drug for diabetic Macular edema named:
Ranibizumab inj
Thiabendazol
LAMA/LABA
Prasugrel
171 ISO 14000 is primarily concerned with one or more than one of events mentioned below:
Chemical safety
Automotive belts
Quality management
Environmental safety
172 According to a report published in the 'Lancet' and reported in news print media, what is/are Africa's new health problem/s
War and poverty
Famine and disease
Obesity
HIV-AIDS
and both
and
only
only
173 India's First Indigenously developed new medicine by Ranbaxy is
Combination of Arterolane maleate Piperaquine P04
Chloroquine Sulfadoxine Pyrimethamine
Amodiquine Sulfadoxine Pyrimethamine
Artemethur
174 Recently, which of the following anti-epileptic drugs has been reported to reverse memory loss due to Alzheimer's disease in mouse model
Levetiracetam
Phenobarbitone
Ethosuximide
Carbamazepine
175 Which Antidiabetic drug has been recently bannedin India for human use 7
Rosiglitazone
Chlorhexidine
Nateglinide
Acetohexamine
176 What will be the next term in the given sequence Find it from given alternatives. ADE, CFG, EHI, GJK,
IML
ILM
MIL
LMI
177 If means' means' and means' Then what will, be the value of 18 Q 12 P 4 R 5 T 6
53
56
59
65
178 As is related to and is related to will be related to
NP
OR
OQ
PR
179 First word bears some definite relationship with the second. From the given alternatives, select the suitable word for'serial number four, which bears the same relation with the third word, that the second has with the first.
Book: Author: Statue:
Painter
Binder
Sculptor
Calligraphist
180 In a code language means 'Red Colour Chalk', means 'Green Colour Flower' and means 'White Colour Chalk'. What is the code for white 7
4
5
6
181 There are three numbers outside and one number inside of two triangles. They are according to some formula. Find the formula and the number at in the third triangle, from given alternatives.
12
9
7
182 Four numbers in each square are according to some formula. Find it and from that find the value of from given alternatives.
5
6
8
7
183 In a code language P R O B L E M is written as M P E R L O B. How N U M B E R S will be written in that code language?
S N U R E M B
S N R U B M E
S N R U E M B
S N R U M E B
184 Which of the figures in given alternatives belongs to the space marked
185 What will be the next term in the given series? B B C B C D B C D E B C D E F B C D E F G B C D E F
B
G
H
D
186 Which letter should go in the blank space
D
E
F
G
187 In a certain code READ is written as 6 and PAID is written as 46. How RIPE will be written in that code?
4 5
6 5
4 5
4 6
188 Which of the following figures will represent the relationship between ball, football and sphere?
189 There is a definite relationship between figures A and B. Establish the similar relationship between figures C and by choosing a suitable figure from given alternatives.
190 Some boys are standing in a row, facing towards North. Ajay is 12th from left. If he moves four places to right, he appears at the place, 18th from right'. What is the total number of boys in the row?
32
33
34
Information is not sufficient
191 A wooden block is shown in the figure. How many different surfaces does the block have?
8
9
10
7
192 Find the missing terms in the given series: 10, 17, 26,
50, 65
45, 65
50, 60
50, 75
193 The numbers in three figures follow some rule, which is not followed by the numbers in one figure. Find the figure, which is different from others.
194 Out of the four groups of letters, three are similar in some way. Find the odd one.
H K
B D
F I
M P
195 Out of the four given figures, three are similar in some way. Choose the figure which is different from the rest.
196 Select the numbers from given alternatives, which will complete the given sequence. 95, 81, 74
102, 87
102, 88
103, 88
101, 89
197 A figure series is given with a blank space shown by Select the suitable figure from given alternatives, which will continue the same series.
198 The given figun;s definite sequence. Fill in the blank space with the suitable figure from given alternatives which should come next.
199 In column I groups of letters and the codes for them are given, not necessarily in the sequence. Each number stands for a letter. What is the code for
Column I Column II
(Groups of Letters) (Codes)
A N P 5 2 4
N M C 1 2 3
P M A 3 4 1
4
3
2
200 The relation between the two terms to the left of and that between the two terms to the right of is same. Find the term at from given alternatives.
E V
U E
V E
E U
Other Question Papers
Subjects
- animal husbandary and veterinary science
- botany
- chemistry
- commerce
- drugs
- electrical
- english
- forest law act
- general english
- general knowledge
- general studies
- land records
- law
- mechanical engineering
- screening
- zoology