Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
M. Pharm SEMESTER II EXAMINATION SUMMER 2017
Subject Code: 2920103 Date: 29/05/2017
Subject Name: Pharmacometrics and Methods of Biological Evaluation of drugs
Time: 10:30 AM to 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Enlist various methods for evaluation of NSAIDs. Discuss any two in brief.
06

Explain acute, subacute and chronic toxicity. Write in brief about OECD 423 test.
05

Describe methods for testing Carcinogenicity.
05
Q.2

What are the sources and properties of Pyrogens in pharmaceutical products? Discuss LAL test in brief.
06

Write a note on the safety assessment of pharmaceutical packaging material.
05

Describe the various methods for Bioassay with examples.
05
Q.3

Enlist the models for inflammatory bowel disease. Discuss TNBS induced colitis model.
06

Explain the official methods for Microbiological Assay of antibiotics.
05

Discuss in brief the different methods for bioassay of Insulin.
05
Q.4

Discuss in brief the evaluation of Local anesthetics.
06

How will you screen Opiod analgesics?
05

Enumerate various models for glaucoma. Discuss any one in detail.
05
Q.5

What are the various models for evaluation of Antipsychotics? Discuss the cook's pole climbing experiment in detail.
06

Enlist the different models for evaluation of Peptic ulcer. Describe any one in detail.
05

Enumerate different models for screening of Antidepressants. Discuss Porsolt's swim test.
05
Q. 6

Write a note on evaluation of Sympatholytics.
06

How will you evaluate skeletal muscle relaxants?
05

Discuss use of freund's adjuvant in biological screening?
05
Q.7

What are the different models for study of Insulin resistance? Describe anyone in detail.
06

Describe the models for stress induced hypertension.
05

Describe the use of 6-Hydroxydopamine and MPTP in screening of antiparkinson drugs.
05