Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
M.PHARM SEMESTER-II EXAMINATION SUMMER 2017
Subject Code: 2920102 Date: 29/05/2017
Subject Name: Novel Drug Delivery System Part-I
Time: 10:30 AM to 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Discuss the classification, merits and demerits of GRDDS.
06

Comment: Osmotic tablet follows zero order drug release pattern.
05

How will you evaluate the colon targeted drug delivery system?
05
Q.2

Explain the specific evaluation parameters for floating tablet.
06

Comment: Colon is a specific site for proteins and peptide drug delivery system.
05

Explain the anatomy and physiology of human buccal mucosa.
05
Q.3

Explain the physicochemical, dosage form related and physiological parameters for selection of drug for GRDDS.
06

Comment: the onset of action of buccal drug delivery is slow.
05

Give the merits and demerits of osmotic drug delivery system. Discuss osmogens.
05
Q.4

Give the different techniques for modified release capsule.
06

Comment: Diltiazem hydrochloride can be incorporated in buccal formulation.
05

Explain the techniques for production of liposome for parenteral delivery.
05
Q.5

Explain the different taste masking techniques with suitable examples.
06

Give the broad classification of novel parenteral drug delivery system.
05

Write a short note on recent innovation in liquid formulation.
05
Q. 6

Give the importance of extractable and leachable for selection of containers and closures.
06

Explain the different types of plastics used in containers with their characteristics.
05

Write a short note on formulation of sublingual dosage form with selection of drug.
05
Q.7

What is secondary packaging? Give its importance for stability of product.
06

Explain the particle coating techniques with its demerits.
05

Explain the formulation of rubber closures. Explain the demerits of rubber closures.
05