Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
M. Pharm SEMESTER-II EXAMINATION SUMMER-2017
Subject Code: 2920101 Date: 29/05/2017
Subject Name: Advanced Organic Chemistry-II
Time: 10:30 AM to 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Discuss in detail about Dimorth and Lossen-Schmidt rearrangement
08

Write synthon approach for losartan and captopril
08
Q.2

Give principle and application of ultrasound reactions
08

What is rearrangement reaction? Discuss reaction and mechanism involve in Bayer- Villiger rearrangement reaction with suitable example.
08
Q.3

What are the merits and demerits of solvent free reactions in synthesis? Give some examples of reactions carried out with solid support
08

Discuss mechanism and applications of curtius and sharpless oxidation
08
Q.4

Write a note on resolution of racemic mixture and recemic switches
08

Compare conventional and microwave assisted organic synthesis with examples
08
Q.5

Define optical isomerism and discuss various methods for the resolution of racemic mixture
08

Discuss the stereochemistry of compounds with asymmetric plane
08
Q. 6

Explain the terms: 1. Atom economy 2. Geometrical isomers
3. Racemic mixture
06

Write reaction, mechanism and applications of benzillic acid rearrangement
05

Write a note on swern oxidation
05
Q.7

How to design safer chemicals. Write benefits and industrial applications of green chemistry
08

Discuss asymmetric synthesis of atenolol and ampicillin
08