Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B. PHARM. SEMESTER-I • EXAMINATION SUMMER 2017
Subject Code: 2210001 Date: 30/05/2017
Subject Name: Unit Operation I
Time: 02:30 PM to 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Discuss in detail factors affecting on size reduction
06

Define size reduction. Discuss mechanisms of size reduction with suitable diagram
05

Write a note on principle, construction, working, advantages, disadvantages and applications of ball mill with labeled diagrams
05
Q.2

Define and classify the powder as per IP and enlist the specification of sieves
06

Describe with a clean and labeled diagram the construction, principle, working, advantages, disadvantages and applications of Rotex Screen.
05

Discuss in detail elutriation method used for size separation
05
Q.3

Define mixing and write its applications in pharmacy. Discuss solid -solid mixing mechanism
06

Explain principle, material of construction, applications, advantages and disadvantages of planetary mixer
05

Discuss in detail with suitable examples positive mixing, negative mixing and neutral mixing.
05
Q.4

Write a note on Mier's supersaturation theory with its limitation and application
06

Define caking of crystals. Explain factors affecting and prevention of caking
05

Discuss the principle, construction, working, advantages, disadvantages and applications of Swenson walker crystallizer with labeled diagrams
05
Q.5

Enlist the type of extraction process and discuss soxhlet extractor in detail
06

Write applications of extraction in field of pharmacy
05

Discuss in detail supercritical fluid extraction technique
05
Q. 6

Write a note on elements of automatic process control systems
06

Discuss automation in flow level and their measurement control
05

Discuss principle, construction, working, advantages, disadvantages and applications of fluid energy mill with labeled diagrams
05
Q.7

Describe in detail prevention of mechanical and chemical hazards
06

Write a note on waste water system in pharmaceutical industry
05

Draw neat and labeled diagram of mechanism of crystallization and explain in detail
05