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Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Pharm. SEMESTER I • EXAMINATION SUMMER 2017
Subject code: 2210003 Date: 06/06/2017
Subject Name: Pharmaceutical Analysis-I
Time: 02:30 PM to 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Answer the following:
1. Define precision, accuracy, oxidation, ligand
2. Disodium edetate is a hexadentate ligand. Comment.
3. Differentiate iodimetry and iodometry.
06

Define validation and explain various analytical validation parameters.
05

What is volumetric analysis? Write principles of volumetric analysis. How detection of end point is done in volumetric analysis?
05
Q.2

Explain hydrolysis of salts, and derive an equation for hydrolysis of salt of weak acid and strong base.
06

50 ml of 0.1M acetic acid is titrated with 0.1 M sodium hydroxide. Calculate the pH of solution when following volume of NaOH is added, 0 ml, 10 ml,
25 ml, 50 ml. Ka of acetic acid 1.8 10-5
05

Explain neutralization theory for acid base indicators.
05
Q.3

What is Argentimetric titration? Describe Mohr's method for determination of chloride?
06

Derive Henderson-Hasselbach equation for buffer solution.
05

Write a brief note on non-aqueous titrations.
05
Q.4

Write a brief note on:
1. Ionic product of water
2. Kjeldahl method
06

Explain various precipitation techniques in gravimetric analysis.
05

Differentiate co-precipitation and post-precipitation.
05
Q.5

Write a detailed note on Permanganate method.
06

Answer the following:
1. Standardization of sodium thiosulphate solution.
2. Standardization of iodine solution
05

Write a detailed note on Redox indicators
05
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Q. 6

Answer the following:
1. Ligands
2. Classification of analytical methods
06

Explain complexometric titration and masking agent with example. What are the ideal requirements of metal ion indicators?
05

Explain common ion effect and diverse ion effect with example.
05
Q. 7

What is error? Classify it, How errors can be minimized?
06

Explain in detail principle, instrumentation and applications of Karl Fischer titration.
05

Explain adsorption indicator method for precipitation.
05