Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B. PHARM SEMESTER V EXAMINATION SUMMER 2017
Subject code: 250003 Date: 31/05/2017
Subject Name: Pharmaceutical Chemistry-V
Time: 10.30 PM to 1.30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Define the terms enantiomers, epimers and anomers with reference to carbohydrates.
06

Discuss the levels of structures found in a protein molecule.
05

Give name and structure of a/an achiral amino acid, reducing disaccharide, non-reducing disaccharide, androgen, glucocorticoid
05
Q.2

Define the terms saponification value, acid value and iodine value explaining their significance.
06

What are different ways of amino acid classification? Classify amino acids according to the side chain giving structure of one example from each class.
05

Write short notes on rancidity heteroglycans
05
Q.3

Write in brief about pentose phosphate pathway uronic acid pathway
06

Discuss the difference in glycogenesis and glycogenolysis.
05

Draw citric acid cycle discussing its biochemical significance and derive its energetics.
05
Q.4

Explain giving pathways how gluconeogenesis is not just a reversal of glycolysis.
06

Discuss biochemical importance of fructose and galactose metabolism.
05

Describe how hormones in accordance with enzymes manage blood sugar level.
05
Q.5

Discuss the role of enzymes in disease diagnosis and therapeutics.
06

Describe giving example various modes of enzyme inhibition
05

Define the terms zymogen, apoenzyme, isozyme, absolute specificity, group specificity
05
Q. 6

Give structure and co-enzymatic function of thiamin, riboflavin and folic acid.
06

Give structure and co-enzymatic function of niacin, pyridoxine and ascorbic acid.
05

Give a brief account of production and biological significance of ATP.
05
Q. 7

Describe in short the routes of transport across cell membrane.
06

Write function of important cellular components.
05

What are bioenergetics? Discuss their biochemical importance.
05