FACULTY OF PHARMACY
B. Pharmacy 4/4 I Semester (Main) Examination, October 2016
Subject: Biopharmaceutics Pharmacokinetics
Time: 3 Hours Max.Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 What are various mechanisms of drug absorption? Discuss the mechanism of
passive diffusion. 7
Discuss the physicochemical factors affecting the absorption of drugs. 7
OR
Explain briefly about various theories proposed for dissolution. 7
Write a note on pH partition theory. Mention its importance. 7
2 How do you determine binding constants and binding sites by graphical methods. 7
Explain the significance of protein binding. 7
OR
Briefly describe the process of drug distribution in the body and enumerate the
factors affecting it. 7
Explain permeability rate limited and perfusion rate limited drug distribution. 7
3 Explain how biotransformation takes place and discuss the factors affecting
biotransformation. 14
OR
Explain entero hepatic cycling. 7
Explain factors affecting the renal excretion of drugs. 7
4 Explain methods of adjustment of dose and dosage regimen in patients with hepatic
failure. 7
What is the significance of half life of drugs? What do you understand by the terms
"Cmax", "tmax", "MEC" and therapeutic index. 7
OR
What are various methods for calculation of AUC? 7
Write in detail about pharmacokinetic drug interactions and its significance in
combination therapy. 7
5 Discuss the method of residual for calculation of absorption rate constant. 7
Write about the Wagner Nelson method used for the determination of absorption
rate constant from the plasma drug concentration time data that follows one
compartment open model. 7
OR
A dose of 325 mg of drug was given intravenously to a patient and following blood
data was obtained. Assuming that the drug follows one compartment open model.
Calculate all possible pharmacokinetic parameters. 14
Time 2 4 6 8 10 12 16 20
Plasma concentration 18.3 10.1 5.8 3.3 1.8 1.0 0.31 0.12